Optimising immunisation in children with 22q11 microdeletion
| Autor: | Vinita Prasad, Helen Heussler, Julia E Clark, Kahn Preece, Sophie C H Wen, Vanil Varghese, Angela Berkhout |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
velo-cardiofacial syndrome
0301 basic medicine lcsh:Immunologic diseases. Allergy Pediatrics medicine.medical_specialty business.industry lcsh:RM1-950 immunisation medicine.disease 22q11 microdeletion syndrome 03 medical and health sciences 030104 developmental biology 0302 clinical medicine lcsh:Therapeutics. Pharmacology 030225 pediatrics DiGeorge syndrome medicine 22q11 microdeletion business lcsh:RC581-607 Immunodeficiency Original Research |
| Zdroj: | Therapeutic Advances in Vaccines and Immunotherapy, Vol 8 (2020) Therapeutic Advances in Vaccines and Immunotherapy |
| ISSN: | 2515-1363 |
| Popis: | Background: The condition known as 22q11 microdeletion syndrome has a broad phenotypic spectrum, with many affected individuals experiencing mild-to-moderate immunodeficiency. Currently, there are significant variations in live vaccine practices and immunological testing prior to live vaccine administration due to safety concerns and limited established guidelines. Methods: Queensland Children’s Hospital (QCH) Child Development Unit, offers a state-wide 22q11 microdeletion clinic. This is a retrospective single-centre review, capturing the majority of children with 22q11 microdeletion in Queensland, Australia. We describe the live vaccination status of 134 children, age 0 to 18 years under our care between 2000 and 2018, adverse events following immunisation (AEFI) and the proportion of children who received additional pneumococcal coverage. An immunological investigation pathway prior to live vaccine administration is proposed. Results: Of the 134 children, 124 were eligible for live vaccinations as per the Australian National Immunisation Program: 82% had received dose one of measles, mumps and rubella (MMR) vaccine, 77% had completed MMR dose two and 66% had completed varicella immunisation. There were no AEFI notifications reported. Of the total sample of children, 18% received a fourth dose of conjugate pneumococcal vaccine (Prevenar 7 or 13) and 16% received a dose of Pneumovax 23 from 4 years of age. Immunology workup practices were demonstrated to vary widely prior to live vaccine administration. Most patients’ immune profiles were consistent with mild-to-moderate immunodeficiency. Conclusion: We propose an immunological investigation and vaccination pathway with the aim of providing guidance and consistency to clinicians caring for children with 22q11 microdeletion. |
| Databáze: | OpenAIRE |
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