Pulmonary Function Parameters in High-resolution Computed Tomography Phenotypes of Chronic Obstructive Pulmonary Disease
| Autor: | Huan Ying Wan, Shu Yi Gu, Qing Yun Li, Ji Min Shen, Lei Ren, Wei Wu Deng, Xian Wen Sun, Shaoguang Huang |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Vital capacity High-resolution computed tomography Pathology Pulmonary function testing Pulmonary Disease Chronic Obstructive FEV1/FVC ratio Internal medicine medicine Humans Pathological Aged Aged 80 and over COPD medicine.diagnostic_test business.industry General Medicine Odds ratio Middle Aged respiratory system medicine.disease Phenotype Respiratory Function Tests respiratory tract diseases ROC Curve Multivariate Analysis Cardiology Female Tomography X-Ray Computed business |
| Zdroj: | The American Journal of the Medical Sciences. 349:228-233 |
| ISSN: | 0002-9629 |
| DOI: | 10.1097/maj.0000000000000395 |
| Popis: | Background Heterogeneity of clinical presentation of chronic obstructive pulmonary disease (COPD) attributes to different pathological basis. High-resolution computed tomography (HRCT) phenotypes of COPD may reflex the pathological basis of COPD indirectly by evaluating the small airway inflammation and emphysema. How the pulmonary function related with different HRCT phenotypes has not been well known. The aim was to explore the features of pulmonary function parameters in the 3 phenotypes. Methods Sixty-three stable COPD patients were allocated in 3 groups based on HRCT findings: phenotype A (absence of emphysema, with minimal evidence of emphysema with or without bronchial wall thickening [BWT]), phenotype E (emphysema without BWT) and phenotype M (emphysema with BWT). The pulmonary function testing was also analyzed. Results The values of forced expiratory volume in 1 second (FEV 1 )/forced vital capacity (FVC%), FEV 1 % and maximum expiratory flows (MEF) 50 % were the highest in phenotype A ( P P 50 /MEF 25 ratio > 4.0 were more prevalence in phenotype A than in E and M (odds ratio = 2.214; P 0.05). The occurrences of RV/TLC% > 40% were higher in phenotype E than in A and M (odds ratio = 3.906; P 0.05). Receiver operating characteristic analysis showed that the cutoff value of MEF 50 /MEF 25 ratio for identifying phenotype A was 2.5, with sensitivity 66.7% and specificity 92.9%. The cutoff value of RV/TLC% for identifying phenotype E was 57.4%, with sensitivity 75.0% and specificity 79.1%. Conclusions The different features of pulmonary function parameters were found in various HRCT phenotypes; MEF 50 /MEF 25 ratio could imply phenotype A, whereas RV/TLC% may be the indicator of phenotype E. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|