A Phase I Study of Chemically Synthesized Verotoxin (Shiga-like Toxin) Pk-Trisaccharide Receptors Attached to Chromosorb for Preventing Hemolytic-Uremic Syndrome
| Autor: | Hermy Lior, Colline Blanchard, Glen D. Armstrong, Peter C. Rowe, Brad Thompson, George A. Wells, Peter N. McLaine, Paul Goodyer, Andrew M. Mackenzie, Francois Auclair, Elaine Orrbine, Rafter David John, Terry P. Klassen |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
medicine.drug_class Polymyxin Bacterial Toxins Molecular Sequence Data Receptors Cell Surface Biology Shiga Toxin 1 medicine.disease_cause Absorption Microbiology Feces chemistry.chemical_compound Shiga-like toxin Double-Blind Method medicine Humans Immunology and Allergy Child Receptor Escherichia coli Gastrointestinal tract Toxin Human gastrointestinal tract Middle Aged Colitis Diatomaceous Earth In vitro Infectious Diseases medicine.anatomical_structure Carbohydrate Sequence chemistry Hemolytic-Uremic Syndrome Glycolipids Trisaccharides |
| Zdroj: | Journal of Infectious Diseases. 171:1042-1045 |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | A double-blind, placebo-controlled study was conducted to document possible side effects associated with oral consumption of synthetic verotoxin (VT, shiga-like toxin) Pk-trisaccharide receptor sequences attached to Chromosorb (Synsorb-Pk) by healthy adult volunteers. Synsorb-Pk reclaimed from volunteer stool samples was also analyzed to determine if its VT-binding activity was affected by exposure to the pH extremes and digestive processes of the human gastrointestinal tract. No participant reported any Synsorb-Pk-related adverse reactions, and no clinically important trends in laboratory data were evident. Synsorb-Pk recovered from stools retained its ability to absorb VT in polymyxin extracts of VT-producing Escherichia coli and also neutralized VT when mixed in vitro with VT-positive stools from children with hemorrhagic colitis or hemolytic-uremic syndrome (HUS). These results suggest a potential use for Synsorb-Pk in preventing HUS in patients infected with VT-producing E. coli. |
| Databáze: | OpenAIRE |
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