Facilitation of Th1-mediated immune response by prostaglandin E receptor EP1
| Autor: | Tomoyuki Furuyashiki, Yoshiki Miyachi, Takahiko Murata, Miyako Nagamachi, Shuh Narumiya, Kenji Kabashima, Toshiyuki Matsuoka, Kitipong Soontrapa, Daiji Sakata, Eri Segi-Nishida |
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| Rok vydání: | 2007 |
| Předmět: |
Agonist
endocrine system Adoptive cell transfer medicine.medical_specialty medicine.drug_class Cellular differentiation medicine.medical_treatment Immunology Antigen-Presenting Cells Biology Article Dinoprostone Mice Th2 Cells Immune system T-Lymphocyte Subsets Internal medicine medicine Animals Receptors Prostaglandin E Immunology and Allergy Prostaglandin E2 Antigen-presenting cell Mice Knockout Cell Differentiation Articles Dendritic Cells Th1 Cells Receptors Prostaglandin E EP1 Subtype Molecular biology Endocrinology Cinnamates Prostaglandins lipids (amino acids peptides and proteins) Lymph Nodes Lymph medicine.drug Prostaglandin E |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 1540-9538 0022-1007 |
| Popis: | Prostaglandin E2 (PGE2) exerts its actions via four subtypes of the PGE receptor, EP1–4. We show that mice deficient in EP1 exhibited significantly attenuated Th1 response in contact hypersensitivity induced by dinitrofluorobenzene (DNFB). This phenotype was recapitulated in wild-type mice by administration of an EP1-selective antagonist during the sensitization phase, and by adoptive transfer of T cells from sensitized EP1−/− mice. Conversely, an EP1-selective agonist facilitated Th1 differentiation of naive T cells in vitro. Finally, CD11c+ cells containing the inducible form of PGE synthase increased in number in the draining lymph nodes after DNFB application. These results suggest that PGE2 produced by dendritic cells in the lymph nodes acts on EP1 in naive T cells to promote Th1 differentiation. |
| Databáze: | OpenAIRE |
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