Anti-histaminic, anti-inflammatory and bronchorelaxant activities of 2, 7-dimethyl-3-nitro-4H pyrido [1,2-a] pyrimidine-4-one
| Autor: | Sarang Bani, G.D. Singh, Peerzada Kaiser, M.S. Youssouf, V. K. Gupta, K. A. Suri, Naresh Kumar Satti, Satyawan Singh, R.K. Johri |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Ketotifen
Male Pyridines Immunology Anti-Inflammatory Agents Histamine H1 receptor Pyrimidinones Pharmacology chemistry.chemical_compound Mice medicine Immunology and Allergy Animals Edema Rats Wistar Mice Inbred BALB C biology Chemistry Compound 48/80 Eosinophil Mast cell Bronchodilator Agents Rats Eosinophils Trachea Ovalbumin medicine.anatomical_structure biology.protein Histamine H1 Antagonists Cytokines Eosinophil peroxidase Histamine medicine.drug |
| Zdroj: | International immunopharmacology. 8(7) |
| ISSN: | 1567-5769 |
| Popis: | An immunopharmacological profile of 2, 7-dimethyl-3-nitro-4H pyrido [1,2-a] pyrimidine-4-one (P-I) has been investigated using in vitro and in vivo models representing various features of Type I allergy. P-I prevented compound 48/80-mediated histamine release from rat peritoneal mast cells. A promising anti-inflammatory activity of P-I was evident in active paw anaphylaxis (mice) and carragenan-induced paw edema (rat). P-I inhibited eosonophil accumulation and eosinophil peroxidase activity in bronchoalveolar lavage fluid from ovalbumin challenged balb/c mice: in these animals blood levels of IL-5, and CD4+ T cells also remained attenuated. A promising bronchorelaxant effect of P-I was observed in histamine-contracted guinea pig tracheal chain via its antagonism to H1 receptor. These findings were compared with some known compounds (ketotifen, cetirizine and promethazine). The anti-histaminic, anti-inflammatory and bronchorelaxant activities of P-I has been discussed in context with its potential profile as an anti-allergic and anti-asthmatic agent. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect