Fecal short-chain fatty acids at different time points after ceftriaxone administration in rats
| Autor: | O. O. Holubenko, Ganna Tolstanova, T. M. Serhiychuk, A. M. Ostapchuk, L. V. Zakordonets, Yu. V. Holota |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Time Factors Microbial metabolism Injections Intramuscular Biochemistry Drug Administration Schedule Caproic Acid antibiotics Butyric acid lcsh:Biochemistry Feces 03 medical and health sciences chemistry.chemical_compound Acetic acid Hemiterpenes 0302 clinical medicine Internal medicine medicine Animals lcsh:QD415-436 Rats Wistar Pentanoic Acids Caproates Acetic Acid colon Chemistry Fatty Acids Volatile Anti-Bacterial Agents Rats Surgery ceftriaxone Butyrates 030104 developmental biology Endocrinology 030220 oncology & carcinogenesis Ceftriaxone Fermentation Propionates Anaerobic exercise medicine.drug |
| Zdroj: | Ukrainian Biochemical Journal, Vol 89, Iss 1, Pp 50-58 (2017) |
| ISSN: | 2413-5003 2409-4943 |
| Popis: | Short-chain fatty acids (SCFAs) are major products of the microbial fermentation of dietary fiber in the colon. Recent studies suggest that these products of microbial metabolism in the gut act as signaling molecules, influence host energy homeostasis and play major immunological roles. In the present study, defined the long-term effects of ceftriaxone administration on the fecal SCFAs concentration in Wistar rats. Ceftriaxone (300 mg/kg, i.m.) was administered daily for 14 days. Rats were euthanized in 1, 15 and 56 days after ceftriaxone withdrawal. Caecal weight and fecal concentration of SCFAs by gas chromatography were measured. Ceftriaxone administration induced time-dependent rats’ caecal enlargement through accumulation of undigestable substances. In 1 day after ceftriaxone withdrawal, the concentrations of acetic, propionic, butyric acids and total SCFAs were decreased 2.9-, 13.8-, 8.5-, 4.8-fold (P < 0.05), respectively. Concentration of valeric, isovaleric and caproic acids was below the detectable level. That was accompanied by decreased 4.3-fold anaerobic index and increased the relative amount of acetic acid (P < 0.05). In 56 days, concentration of SCFAs was still below control value but higher than in 1 day (except propionic acid). Anaerobic index was lower 1.3-fold (P < 0.05) vs. control. Conclusion: antibiotic therapy induced long-term disturbance in colonic microbiota metabolic activity. |
| Databáze: | OpenAIRE |
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