Atropine for Critical Care Intubation in a Cohort of 264 Children and Reduced Mortality Unrelated to Effects on Bradycardia
| Autor: | Corinne Alberti, Katia Kessous, Peter B. Jones, Nathalia Pinto da Costa, Tobias Kurth, Stéphane Dauger, Noella Lode, Mark J. Peters |
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| Rok vydání: | 2013 |
| Předmět: |
Atropine
Male Pediatrics Anatomy and Physiology Critical Care and Emergency Medicine medicine.medical_treatment lcsh:Medicine Cardiovascular Cardiovascular System Cohort Studies 0302 clinical medicine Pediatric Cardiology Intubation Prospective Studies lcsh:Science Child Prospective cohort study Multidisciplinary Mortality rate Clinical Pharmacology 3. Good health Child Preschool Anesthesia Cohort Medicine Female medicine.symptom Research Article medicine.drug Cohort study Bradycardia Drugs and Devices Pediatric Critical Care medicine.medical_specialty Critical Care Critical Care Team Organization Cardiovascular Pharmacology 03 medical and health sciences 030225 pediatrics Heart rate medicine Humans business.industry lcsh:R Infant Newborn Hemodynamics Infant 030208 emergency & critical care medicine lcsh:Q business |
| Zdroj: | PLoS ONE PLoS ONE, Vol 8, Iss 2, p e57478 (2013) |
| ISSN: | 1932-6203 |
| Popis: | Background Atropine has is currently recommended to facilitate haemodynamic stability during critical care intubation. Our objective was to determine whether atropine use at induction influences ICU mortality. Methodology/Principal Findings A 2-year prospective, observational study of all first non-planned intubations, September 2007–9 in PICU and Intensive Care Transport team of Hôpital Robert Debré, Paris, 4 other PICUs and 5 NICUs in the Paris Region, France. Follow-up was from intubation to ICU discharge. A propensity score was used to adjust for patient specific characteristics influencing atropine prescription. 264/333 (79%) intubations were included. The unadjusted ICU mortality was 7.2% (9/124) for those who received atropine compared to 15.7% (22/140) for those who did not (OR 0.42, 95%CI 0.19–0.95, p = 0.04). One child died during intubation (1/264, 0.4%). Two age sub-groups of neonates (≤28 days) and older children (>28 days |
| Databáze: | OpenAIRE |
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