Chronic kidney disease and the risk of stent thrombosis after percutaneous coronary intervention with drug-eluting stents

Autor: Zhao Yingxin, Yu Miao, Yang Shiwei, Jia Dean, Zhou Yujie, Wang Zhijian, Shi Dongmei, Liu Yuyang, Gao Fei
Rok vydání: 2012
Předmět:
Male
China
medicine.medical_specialty
Time Factors
medicine.medical_treatment
Myocardial Infarction
Renal function
Coronary Artery Disease
Kaplan-Meier Estimate
Kidney
Prosthesis Design
urologic and male genital diseases
Risk Assessment
Coronary artery disease
Percutaneous Coronary Intervention
Risk Factors
Internal medicine
medicine
Humans
Radiology
Nuclear Medicine and imaging
Prospective Studies
Renal Insufficiency
Chronic
Aged
Proportional Hazards Models
Chi-Square Distribution
business.industry
Coronary Thrombosis
Incidence
Hazard ratio
Percutaneous coronary intervention
Stent
Drug-Eluting Stents
General Medicine
Middle Aged
medicine.disease
Treatment Outcome
Drug-eluting stent
Conventional PCI
Cardiology
Female
Cardiology and Cardiovascular Medicine
business
Glomerular Filtration Rate
Kidney disease
Zdroj: Catheterization and Cardiovascular Interventions. 80:361-367
ISSN: 1522-1946
DOI: 10.1002/ccd.23464
Popis: Background Chronic kidney disease (CKD) has been demonstrated to be associated with adverse clinical outcomes for patients with coronary artery disease (CAD). However, data on relation of CKD and stent thrombosis (ST) after drug-eluting stent (DES) implantation are limited. Objectives This study was designed to examine whether CKD is associated with higher incidence of ST after elective coronary DES implantation compared with patients with normal renal function. Methods We consecutively enrolled 2,862 patients undergoing elective percutaneous coronary intervention (PCI) with DES. Demographic and clinical data were collected preoperatively. CKD was defined as estimated glomerular filtration rate (eGFR) < 60 ml/min, calculated using the modified MDRD equation. The primary outcome was 1-year definite or probable ST. Results Four hundred and forty-five participants (15.5%) had CKD before procedure. The incidence of 1-year definite or probable ST was significantly higher in CKD patients compared with patients with normal renal function (1.8% vs. 0.6%, P = 0.014). After adjustment for multiple clinical and biochemical covariates, CKD was an independent predictor of 1-year definite or probable ST (hazard rate [HR] 0.396, 95% CI 0.165–0.951, P = 0.038). Conclusion CKD is significantly associated with increased incidence of 1-year definite or probable ST in patients undergoing PCI with DES. © 2012 Wiley Periodicals Inc.
Databáze: OpenAIRE
Externí odkaz: