Principles and roles of mRNA localization in animal development
| Autor: | Florence Besse, Kimberly L. Mowry, Caroline Medioni |
|---|---|
| Přispěvatelé: | Institut de Biologie Valrose (IBV), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Université Nice Sophia Antipolis (1965 - 2019) (UNS), Brown University, MEDIONI, Caroline |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Cytoplasm
RNA localization [SDV]Life Sciences [q-bio] MESH: Asymmetric Cell Division Reviews Biology 03 medical and health sciences 0302 clinical medicine Cell polarity Asymmetric cell division Animals MESH: Animals RNA Messenger Molecular Biology [SDV.BDD]Life Sciences [q-bio]/Development Biology 030304 developmental biology Body Patterning MESH: RNA Messenger 0303 health sciences Mechanism (biology) MESH: Cytoplasm Asymmetric Cell Division Cell Polarity Cell migration Embryonic stem cell Cell biology [SDV] Life Sciences [q-bio] MESH: Cell Polarity 030217 neurology & neurosurgery Intracellular Developmental Biology MESH: Body Patterning |
| Zdroj: | Development (Cambridge, England) Development (Cambridge, England), Company of Biologists, 2012, 139 (18), pp.3263-76. ⟨10.1242/dev.078626⟩ Development (Cambridge, England), 2012, 139 (18), pp.3263-3276. ⟨10.1242/dev.078626⟩ |
| ISSN: | 1477-9129 0950-1991 |
| DOI: | 10.1242/dev.078626⟩ |
| Popis: | International audience; Intracellular targeting of mRNAs has long been recognized as a means to produce proteins locally, but has only recently emerged as a prevalent mechanism used by a wide variety of polarized cell types. Localization of mRNA molecules within the cytoplasm provides a basis for cell polarization, thus underlying developmental processes such as asymmetric cell division, cell migration, neuronal maturation and embryonic patterning. In this review, we describe and discuss recent advances in our understanding of both the regulation and functions of RNA localization during animal development. |
| Databáze: | OpenAIRE |
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