FERTILITY STUDY ON HALOPREDONE ACETATE IN RATS
| Autor: | Jun-ichi Sudo, Seiichi Imoto, Megumi Kosaka, Tsuneyoshi Tanabe, Kotaro Shinpo, Masaya Takeuchi, Satoru Kamada, Akiko Yahata |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Male
Fetus Halopredone acetate medicine.drug_class media_common.quotation_subject Body Weight Fertility Study Anti-Inflammatory Agents Physiology Rats Inbred Strains Fertility Gestation period Biology Toxicology Rats Copulation medicine Animals Corticosteroid Gestation Female Fluprednisolone Mating media_common |
| Zdroj: | The Journal of Toxicological Sciences. 10:71-81 |
| ISSN: | 1880-3989 0388-1350 |
| DOI: | 10.2131/jts.10.supplementi_71 |
| Popis: | A fertility study of halopredone acetate (THS-201), a synthetic corticosteroid, was carried out using Jcl: Wistar rats. Male rats were treated subcutaneously for 63 days before mating and throughout mating, and female rats were treated subcutaneously for 14 days before mating and until day 7 of gestation, in doses of 0.04, 0.2, 1.0 and 5.0 mg/kg/day. Male and female rats in the same dose were mated. All of the pregnant rats were killed on day 20 of gestation and their fetuses were examined morphologically. The results obtained from the present study were as follows. A decrease in body weight gain was observed in male rats of 1.0 and 5.0 mg/kg groups, compared to the vehicle control group. In female rats of 5.0 mg/kg group, a decrease in body weight gain during gestation period was observed. However, no influences attributable to THS 201 administration were observed on the fertility and fetal development. These results indicated that the non-effect dose of THS-201 for the fertility of rats and fetal development was 5.0 mg/kg/day. |
| Databáze: | OpenAIRE |
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