Magnetic nanosystem for cancer therapy using oncocalyxone a, an antitomour secondary metabolite isolated from a Brazilian plant

Autor: Pierre Basílio Almeida Fechine, Luigi Carbone, Otília Deusdênia L. Pessoa, Maria Elenir Nobre Pinho Ribeiro, Giuseppe Mele, Selma Elaine Mazzetto, Juliano C. Denardin, A. C. H. Barreto, Tamara Gonçalves, Igor Marques Cavalcante, Nágila M.P.S. Ricardo, Telma L. G. Lemos, Vivian Romero Santiago, Rafael M. Freire
Přispěvatelé: Barreto, Antônio C. H., Santiago, Vivian R., Freire, Rafael M., Mazzetto, Selma E., Denardin, Juliano C., Mele, Giuseppe, Cavalcante, Igor M., Ribeiro, Maria E. N. P., Ricardo, Nágila M. P. S., Gonçalves, Tamara, Carbone, Luigi, Lemos, Telma L. G., Pessoa, Otília D. L., Fechine, Pierre B. A.
Rok vydání: 2013
Předmět:
Cancer therapy
Magnetic nanoparticle
Oncocalyxone A
Anthraquinones
Catalysi
lcsh:Chemistry
chemistry.chemical_compound
Nuclear magnetic resonance
Drug Delivery Systems
Spectroscopy
Fourier Transform Infrared
Magnetite Nanoparticles
lcsh:QH301-705.5
Spectroscopy
media_common
Chemistry
Computer Science Applications1707 Computer Vision and Pattern Recognition
General Medicine
Boraginaceae
oncocalyxone A
Computer Science Applications
Drug delivery
cancer therapy
medicine.drug
Drug
magnetic nanoparticles
media_common.quotation_subject
Antineoplastic Agents
Secondary metabolite
Catalysis
Article
Inorganic Chemistry
Magnetization
Magnetics
Microscopy
Electron
Transmission
medicine
Physical and Theoretical Chemistry
drug delivery
Molecular Biology
Plant Extracts
Organic Chemistry
lcsh:Biology (General)
lcsh:QD1-999
Magnetic nanoparticles
human activities
Nuclear chemistry
Zdroj: International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 14; Issue 9; Pages: 18269-18283
International journal of molecular sciences (Online) 14 (2013): 18269–18283. doi:10.3390/ijms140918269
info:cnr-pdr/source/autori:Barreto, Antonio C. H.; Santiago, Vivian R.; Freire, Rafael M.; Mazzetto, Selma E.; Denardin, Juliano C.; Mele, Giuseppe; Cavalcante, Igor M.; Ribeiro, Maria E. N. P.; Ricardo, Nagila M. P. S.; Goncalves, Tamara; Carbone, Luigi; Lemos, Telma L. G.; Pessoa, Otilia D. L.; Fechine, Pierre B. A./titolo:Magnetic Nanosystem for Cancer Therapy Using Oncocalyxone A, an Antitomour Secondary Metabolite Isolated from a Brazilian Plant/doi:10.3390%2Fijms140918269/rivista:International journal of molecular sciences (Online)/anno:2013/pagina_da:18269/pagina_a:18283/intervallo_pagine:18269–18283/volume:14
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
International Journal of Molecular Sciences, Vol 14, Iss 9, Pp 18269-18283 (2013)
ISSN: 1422-0067
Popis: This paper describes the investigation and development of a novel magnetic drug delivery nanosystem (labeled as MO-20) for cancer therapy. The drug employed was oncocalyxone A (onco A), which was isolated from Auxemma oncocalyx, an endemic Brazilian plant. It has a series of pharmacological properties: antioxidant, cytotoxic, analgesic, anti-inflammatory, antitumor and antiplatelet. Onco A was associated with magnetite nanoparticles in order to obtain magnetic properties. The components of MO-20 were characterized by XRD, FTIR, TGA, TEM and Magnetization curves. The MO-20 presented a size of about 30 nm and globular morphology. In addition, drug releasing experiments were performed, where it was observed the presence of the anomalous transport. The results found in this work showed the potential of onco A for future applications of the MO-20 as a new magnetic drug release nanosystem for cancer treatment.
Databáze: OpenAIRE
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