Magnetic nanosystem for cancer therapy using oncocalyxone a, an antitomour secondary metabolite isolated from a Brazilian plant
Autor: | Pierre Basílio Almeida Fechine, Luigi Carbone, Otília Deusdênia L. Pessoa, Maria Elenir Nobre Pinho Ribeiro, Giuseppe Mele, Selma Elaine Mazzetto, Juliano C. Denardin, A. C. H. Barreto, Tamara Gonçalves, Igor Marques Cavalcante, Nágila M.P.S. Ricardo, Telma L. G. Lemos, Vivian Romero Santiago, Rafael M. Freire |
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Přispěvatelé: | Barreto, Antônio C. H., Santiago, Vivian R., Freire, Rafael M., Mazzetto, Selma E., Denardin, Juliano C., Mele, Giuseppe, Cavalcante, Igor M., Ribeiro, Maria E. N. P., Ricardo, Nágila M. P. S., Gonçalves, Tamara, Carbone, Luigi, Lemos, Telma L. G., Pessoa, Otília D. L., Fechine, Pierre B. A. |
Rok vydání: | 2013 |
Předmět: |
Cancer therapy
Magnetic nanoparticle Oncocalyxone A Anthraquinones Catalysi lcsh:Chemistry chemistry.chemical_compound Nuclear magnetic resonance Drug Delivery Systems Spectroscopy Fourier Transform Infrared Magnetite Nanoparticles lcsh:QH301-705.5 Spectroscopy media_common Chemistry Computer Science Applications1707 Computer Vision and Pattern Recognition General Medicine Boraginaceae oncocalyxone A Computer Science Applications Drug delivery cancer therapy medicine.drug Drug magnetic nanoparticles media_common.quotation_subject Antineoplastic Agents Secondary metabolite Catalysis Article Inorganic Chemistry Magnetization Magnetics Microscopy Electron Transmission medicine Physical and Theoretical Chemistry drug delivery Molecular Biology Plant Extracts Organic Chemistry lcsh:Biology (General) lcsh:QD1-999 Magnetic nanoparticles human activities Nuclear chemistry |
Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences; Volume 14; Issue 9; Pages: 18269-18283 International journal of molecular sciences (Online) 14 (2013): 18269–18283. doi:10.3390/ijms140918269 info:cnr-pdr/source/autori:Barreto, Antonio C. H.; Santiago, Vivian R.; Freire, Rafael M.; Mazzetto, Selma E.; Denardin, Juliano C.; Mele, Giuseppe; Cavalcante, Igor M.; Ribeiro, Maria E. N. P.; Ricardo, Nagila M. P. S.; Goncalves, Tamara; Carbone, Luigi; Lemos, Telma L. G.; Pessoa, Otilia D. L.; Fechine, Pierre B. A./titolo:Magnetic Nanosystem for Cancer Therapy Using Oncocalyxone A, an Antitomour Secondary Metabolite Isolated from a Brazilian Plant/doi:10.3390%2Fijms140918269/rivista:International journal of molecular sciences (Online)/anno:2013/pagina_da:18269/pagina_a:18283/intervallo_pagine:18269–18283/volume:14 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Artículos CONICYT CONICYT Chile instacron:CONICYT International Journal of Molecular Sciences, Vol 14, Iss 9, Pp 18269-18283 (2013) |
ISSN: | 1422-0067 |
Popis: | This paper describes the investigation and development of a novel magnetic drug delivery nanosystem (labeled as MO-20) for cancer therapy. The drug employed was oncocalyxone A (onco A), which was isolated from Auxemma oncocalyx, an endemic Brazilian plant. It has a series of pharmacological properties: antioxidant, cytotoxic, analgesic, anti-inflammatory, antitumor and antiplatelet. Onco A was associated with magnetite nanoparticles in order to obtain magnetic properties. The components of MO-20 were characterized by XRD, FTIR, TGA, TEM and Magnetization curves. The MO-20 presented a size of about 30 nm and globular morphology. In addition, drug releasing experiments were performed, where it was observed the presence of the anomalous transport. The results found in this work showed the potential of onco A for future applications of the MO-20 as a new magnetic drug release nanosystem for cancer treatment. |
Databáze: | OpenAIRE |
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