A single-cell transcriptomic atlas of the adultDrosophilaventral nerve cord
| Autor: | Aaron M. Allen, Scott Waddell, Christoph Daniel Treiber, Sebastian Birtles, Megan C Neville, Vincent Croset, Stephen F. Goodwin |
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| Rok vydání: | 2019 |
| Předmět: |
Central Nervous System
Nervous system Cell type QH301-705.5 Science Sensory system Biology General Biochemistry Genetics and Molecular Biology Transcriptome 03 medical and health sciences ventral nerve cord 0302 clinical medicine Neuroblast medicine Animals Biology (General) Hox gene Gene 030304 developmental biology Neurons 0303 health sciences D. melanogaster General Immunology and Microbiology General Neuroscience nervous system Genetics and Genomics General Medicine Neuromere Drosophila melanogaster medicine.anatomical_structure Ventral nerve cord Medicine single-cell transcriptomics Neuroscience 030217 neurology & neurosurgery Research Article |
| Zdroj: | eLife, Vol 9 (2020) eLife |
| DOI: | 10.1101/2019.12.20.883884 |
| Popis: | TheDrosophilaventral nerve cord (VNC) receives and processes descending signals from the brain to produce a variety of coordinated locomotor outputs. It also integrates sensory information from the periphery and sends ascending signals to the brain. We used single-cell transcriptomics to generate an unbiased classification of cellular diversity in the VNC of five-day old adult flies. We produced an atlas of 26,000 high-quality cells, representing more than 100 transcriptionally distinct cell types. The predominant gene signatures defining neuronal cell types reflect shared developmental histories based on the neuroblast from which cells were derived, as well as their birth order. Cells could also be assigned to specific neuromeres using adult Hox gene expression. This single-cell transcriptional atlas of the adult fly VNC will be a valuable resource for future studies of neurodevelopment and behavior. |
| Databáze: | OpenAIRE |
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