Catalytic enantioselective Hosomi-Sakurai reaction of α-ketoesters promoted by chiral copper(ii) complexes
| Autor: | Yutaro Niwa, Mayu Miyake, Ichiro Hayakawa, Akira Sakakura |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Allylic rearrangement
Silanes Chemistry Ligand Metals and Alloys Enantioselective synthesis chemistry.chemical_element General Chemistry Oxazoline Medicinal chemistry Copper Catalysis Surfaces Coatings and Films Electronic Optical and Magnetic Materials chemistry.chemical_compound Materials Chemistry Ceramics and Composites Sakurai reaction |
| Zdroj: | Chemical communications (Cambridge, England). 55(27) |
| ISSN: | 1364-548X |
| Popis: | A catalytic enantioselective Hosomi–Sakurai reaction of α-ketoesters has been developed. A copper(II) complex with a chiral bis(oxazoline) ligand bearing methanesulfonamide groups shows excellent catalytic activity to give α,α-disubstituted α-hydroxyesters in high yields with high enantioselectivities. This is the first successful method for the catalytic enantioselective 1,2-addition of α-ketoesters with allylic silanes. |
| Databáze: | OpenAIRE |
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