Crosstalk between p53 modifiers at PML bodies
| Autor: | Thomas G. Hofmann, Sonja Matt |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cancer Research DNA damage Biology medicine.disease law.invention 03 medical and health sciences Crosstalk (biology) Nuclear body Leukemia Author's Views 030104 developmental biology law Apoptosis Cancer research medicine Molecular Medicine Suppressor Protein p53 APL - Acute promyelocytic leukemia |
| Popis: | Tumor protein p53 (TP53, best known as p53), the most frequently mutated tumor suppressor in cancer, plays a central role in cell fate decisions induced by DNA damage. Regulation of p53 activity by post-translational modifications has been linked to promyelocytic leukemia nuclear bodies (PML-NBs), where p53 encounters many of its regulators. Recent evidence implies that crosstalk between p53 regulators at the PML-NB shapes post-translational modifications and function of p53. |
| Databáze: | OpenAIRE |
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