Anemia and the risk of contrast-induced nephropathy in patients with renal insufficiency undergoing contrast-enhanced MDCT
| Autor: | Izumi Miki, Minako Takeda, Hiromitsu Hayashi, Ryusuke Murakami, Emi Okazaki, Hitomi Tani, Tomonari Kiriyama, Shinichiro Kumita, Ken-ichi Sugizaki, Kenta Hakozaki |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Drug-Related Side Effects and Adverse Reactions Anemia Iohexol Contrast-induced nephropathy Contrast Media Comorbidity Hematocrit urologic and male genital diseases Gastroenterology Nephropathy chemistry.chemical_compound Japan Risk Factors Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Renal Insufficiency Risk factor Aged Retrospective Studies Creatinine medicine.diagnostic_test business.industry Incidence (epidemiology) Incidence General Medicine Odds ratio Acute Kidney Injury medicine.disease Causality chemistry Female Kidney Diseases Radiology business Tomography X-Ray Computed |
| Zdroj: | European journal of radiology. 82(10) |
| ISSN: | 1872-7727 |
| Popis: | Purpose The purpose of this study was to assess the effect of anemia on the incidence of contrast-induced nephropathy (CIN) in patients with renal impairment undergoing MDCT. Materials and methods Institutional review board approval was waived for this retrospective review of 843 patients with stable renal insufficiency (eGFR between 15 and 60 mL/min) who had undergone contrast-enhanced MDCT. Baseline hematocrit and hemoglobin values were measured. Serum creatinine (SCr) was assessed at the baseline and at 48–72 h after contrast administration. Results The overall incidence of CIN in the patient population with renal insufficiency was 6.9%. CIN developed in 7.8% (54 of 695) of anemic patients, and in 2.8% (4 of 148) of non-anemic patients (P = .027). After adjustment for confounders, low hemoglobin and low hematocrit values remained independent predictors of CIN (odds ratio 4.6, 95% CI 1.0–20.5, P = .046). Conclusions Anemia is associated with a higher incidence of CIN in patients with renal insufficiency. Anemia is a potentially modifiable risk factor for CIN, and has an unfavorable impact on prognosis in patients with renal insufficiency undergoing contrast-enhanced MDCT. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect