Dynamics of regulatory networks in the developing mouse retina
| Autor: | Laszlo Hackler, Jiang Qian, Hongkai Ji, Donald J. Zack, Woochang Hwang, George Wu |
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| Rok vydání: | 2012 |
| Předmět: |
Anatomy and Physiology
Clinical Research Design lcsh:Medicine Computational biology Biology Bioinformatics Retina Network motif Mice Model Organisms Transcription (biology) Ocular System Animals lcsh:Science Transcription factor Gene Regulation of gene expression Regulatory Networks Multidisciplinary Gene Expression Profiling Systems Biology lcsh:R Modeling Computational Biology Animal Models Molecular Development Network dynamics Gene expression profiling MicroRNAs Medicine lcsh:Q Network analysis Research Article Developmental Biology |
| Zdroj: | PLoS ONE PLoS ONE, Vol 7, Iss 10, p e46521 (2012) |
| ISSN: | 1932-6203 |
| Popis: | Understanding gene regulation is crucial to dissect the molecular basis of human development and disease. Previous studies on transcription regulatory networks often focused on their static properties. Here we used retinal development as a model system to investigate the dynamics of regulatory networks that are comprised of transcription factors, microRNAs and other protein-coding genes. We found that the active sub-networks are topologically different at early and late stages of retinal development. At early stages, the active sub-networks tend to be highly connected, while at late stages, the active sub-networks are more organized in modular structures. Interestingly, network motif usage at early and late stages is also distinct. For example, network motifs containing reciprocal feedback regulatory relationships between two regulators are overrepresented in early developmental stages. Additionally, our analysis of regulatory network dynamics revealed a natural turning point at which the regulatory network undergoes drastic topological changes. Taken together, this work demonstrates that adding a dynamic dimension to network analysis can provide new insights into retinal development, and we suggest the same approach would likely be useful for the analysis of other developing tissues. |
| Databáze: | OpenAIRE |
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