| Autor: |
Wenli Zhang, Junrui Wang, Zhuoyan Xie, Hongmi Zou, Qiaoqi Chen, Lian Xu, Liu Hu, Ni Fang, Jie Xu, Jun Zhou, Jia Liu, Haitao Ran, Zhigang Wang, Yu Zhang, Dajing Guo |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Small (Weinheim an der Bergstrasse, Germany). 18(15) |
| ISSN: |
1613-6829 |
| Popis: |
In thrombotic diseases, the effects of reactive oxygen species (ROS)-mediated oxidative stress as a "perpetrator" in thrombosis must be resolved. Accordingly, an insufficient understanding of thrombus therapy prompted the authors to pursue a more comprehensive and efficient antithrombotic treatment strategy. A Prussian blue (PB)-based nanodroplet system (PB-PFP@PC) is designed using PB and perfluorinated pentane (PFP) in the core, and a targeting peptide (CREKA, Cys-Arg-Glu-Lys-Ala) is attached to poly(lactic-coglycolic acid) (PLGA) as the delivery carrier shell. Upon near-infrared (NIR) laser irradiation, PB and PFP jointly achieve an unprecedented dual strategy for drug-free thrombolysis: photothermal therapy (PTT) combined with optical droplet vaporization (ODV). PB, a nanoenzyme, also regulates the vascular microenvironment via its antioxidant activity to continuously scavenge abnormally elevated ROS and correspondingly reduce inflammatory factors in the thrombus site. This study provides a demonstration of not only the potential of ODV in thrombus therapy but also the mechanism underlying PTT thrombolysis due to thermal ablation-induced fibrin network structural damage. Moreover, PB catalyzes ROS to generate oxygen (O |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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