The era of comparable life expectancy between thalassaemia major and intermedia: Is it time to revisit the major-intermedia dichotomy?
| Autor: | Liana Cuccia, Luciano Prossomariti, Maria Fustaneo, Saveria Campisi, Giuseppina Calvaruso, Michele Rizzo, Francesco Gagliardotto, Grazia Colletta, Aldo Filosa, Rosario Di Maggio, Alessandra Quota, Aurelio Maggio, Vincenzo Caruso, Crocetta Argento, Lorella Pitrolo, Carmelo Fidone, Angela Vitrano, Luciana Rigoli, Calogera Gerardi, Eliana Lai |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Improved survival classification severity survival thalassaemia Adult Female Follow-Up Studies Humans Male Middle Aged Retrospective Studies Survival Rate Young Adult beta-Thalassemia Life Expectancy Hematology Iron chelation 03 medical and health sciences Young Adult 0302 clinical medicine Life Expectancy medicine Humans Retrospective Studies Thalassaemia major business.industry Hazard ratio beta-Thalassemia Hematology Iron chelation therapy Middle Aged Confidence interval Survival Rate 030220 oncology & carcinogenesis Life expectancy Female Intermedia business 030215 immunology Follow-Up Studies |
| Zdroj: | British journal of haematology. 176(1) |
| ISSN: | 1365-2141 |
| Popis: | Summary In the last few decades, the life expectancy of regularly transfused β-thalassaemia major (TM) patients has dramatically improved following the introduction of safe transfusion practices, iron chelation therapy, aggressive treatment of infections and improved management of cardiac complications. How such changes, especially those attributed to the introduction of iron chelation therapy, improved the survival of TM patients to approach those with β-thalassaemia intermedia (TI) remains unknown. Three hundred and seventy-nine patients with TM (n = 284, dead 40) and TI (n = 95, dead 13) were followed retrospectively since birth until 30 June 2015 or death. Kaplan-Meir curves showed statistically significant differences in TM and TI survival (P |
| Databáze: | OpenAIRE |
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