Experience-dependent refinement of inhibitory inputs to auditory coincidence-detector neurons
| Autor: | Hermann Schweizer, Armin H. Seidl, Benedikt Grothe, Christoph Kapfer |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Sound localization
Time Factors Computer science Glycine Context (language use) Olivary Nucleus Inhibitory postsynaptic potential ENCODE Arrival time Receptors Glycine Chiroptera otorhinolaryngologic diseases Animals Sound Localization Rats Wistar Neurons Afferent Pathways Signal processing General Neuroscience Membrane Proteins Opossums Cochlea Rats Synapses Auditory Perception Carrier Proteins Gerbillinae Microtubule-Associated Proteins Neuroscience Coincidence detection in neurobiology Ionotropic effect |
| Zdroj: | Nature Neuroscience. 5:247-253 |
| ISSN: | 1546-1726 1097-6256 |
| DOI: | 10.1038/nn810 |
| Popis: | The spatial arrangement of inputs on to single neurons is assumed to be crucial in accurate signal processing. In mammals, the most precise temporal processing occurs in the context of sound localization. Medial superior olivary neurons can encode microsecond differences in the arrival time of low-frequency sounds at the two ears. Here we show that in mammals with well developed low-frequency hearing, a spatial refinement of ionotropic inhibitory inputs occurs on medial superior olivary neurons during development. This refinement is experience dependent and does not develop in mammals that do not use interaural time differences for sound localization. |
| Databáze: | OpenAIRE |
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