Effect of polyphenolic extract, Pycnogenol, on the level of 8-oxoguanine in children suffering from attention deficit/hyperactivity disorder
| Autor: | Zuzana Chovanová, Jana Muchová, Ingrid Zitnanova, Igor Škodáček, M Sivonova, Zdenka Durackova, Jana Trebatická, Iveta Waczulíková, Monika Dvorakova |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty animal structures Guanine Adolescent DNA damage Placebo-controlled study Biochemistry Antioxidants law.invention Placebos chemistry.chemical_compound Randomized controlled trial Double-Blind Method law Internal medicine medicine Attention deficit hyperactivity disorder Humans Child Flavonoids business.industry Plant Extracts General Medicine medicine.disease Pinus 8-Oxoguanine Antioxidant capacity Endocrinology Treatment Outcome chemistry Polyphenol Attention Deficit Disorder with Hyperactivity Attention deficit Plant Bark Female business DNA Damage |
| Zdroj: | Free radical research. 40(9) |
| ISSN: | 1071-5762 |
| Popis: | The purpose of this randomized, double-blind and placebo controlled study was to test the effect of polyphenolic extract of pine bark Pycnogenol (Pyc) on the level of oxidized purines represented by 8-oxo-7,8-dihydroguanine (8-oxoG) and on the total antioxidant status (TAS) in children with attention deficit/hyperactivity disorder (ADHD).We have found significantly increased damage to DNA in ADHD children when compared to controls. 8-oxoG was significantly lower after 1 month of Pyc administration in comparison to the beginning state and to placebo group. TAS in ADHD children was lower in comparison to controls. After Pyc administration, TAS was elevated but statistically significant increase was recorded after 1 month of termination of Pyc application. Improvement of DNA damage and TAS after Pyc administration is associated with the improvement of attention in ADHD children. In conclusion, Pycnogenol(R) administration reduces oxidative damage to DNA, normalizes TAS and improves attention of ADHD children. Explanation of mutual relation between oxidative damage to DNA, TAS and symptoms of ADHD and mechanism of Pyc's action needs further investigations. |
| Databáze: | OpenAIRE |
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