New diterpenes from Nigella damascena seeds and their antiviral activities against herpes simplex virus type-1
| Autor: | Masahiro Fujimuro, Souichi Nakashima, Keiko Ogawa, Seikou Nakamura, Hanako Ishimaru, Kaori Ryu, Hisashi Matsuda, Natsuki Saito, Kohei Hosokawa |
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| Rok vydání: | 2017 |
| Předmět: |
biology
Traditional medicine 010405 organic chemistry Chemistry Pharmacology toxicology Ranunculaceae Herpesvirus 1 Human biology.organism_classification medicine.disease_cause 01 natural sciences Nigella Antiviral Agents Terpenoid 0104 chemical sciences Nigella damascena 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Herpes simplex virus Seeds medicine Molecular Medicine Diterpene Diterpenes |
| Zdroj: | Journal of natural medicines. 72(2) |
| ISSN: | 1861-0293 |
| Popis: | Nigella species are rich source of dolabellane diterpenes. During our study of Nigella species, new dolabellane diterpenes, damasterpenes V–VIII were isolated. The structural determination of new compounds damasterpenes V–VIII is described with consideration of their absolute configurations. The antiviral activities against herpes simplex virus type-1 of the isolated compounds and their derivatives are also evaluated. Damasterpene V (inhibition 35.0%) and 2-phenylacetyl 13-benzoyl damasterpenol (32.0%) showed significant antiviral activity at 10 μM. |
| Databáze: | OpenAIRE |
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