Mechanical Influence of Surrounding Soft Tissue on Bone Regeneration Processes: A Bone Lengthening Study
| Autor: | Jaime Domínguez, Rocío Navarrete-Calvo, Pablo Blázquez-Carmona, Juan Mora-Macías, Esther Reina-Romo, J.A. Sanz-Herrera, Juan Morgaz |
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| Přispěvatelé: | Junta de Andalucía, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España) |
| Rok vydání: | 2020 |
| Předmět: |
Distraction osteogenesis
Bone Regeneration medicine.medical_treatment 0206 medical engineering education Biomedical Engineering Osteogenesis Distraction Viscoelastic model 02 engineering and technology Bone healing Bone callus behavioral disciplines and activities Surrounding soft tissue Models Biological Bone Lengthening Mechanobiology Distraction In vivo medicine Animals Bone transport Bone regeneration Metatarsal Bones Sheep business.industry Distraction forces Soft tissue 020601 biomedical engineering humanities Biomechanical Phenomena Tissue relaxation Female business psychological phenomena and processes Biomedical engineering |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 1573-9686 |
| Popis: | Bone lengthening is a bone regeneration technique with multiple clinical applications. One of the most common complications of this treatment is the lack of adaptation of the surrounding soft tissue to their extension. A better understanding of the mechanobiology of the tissues involved in distraction osteogenesis would allow better control of the clinical cases. Bone lengthening treatments were performed in vivo in the metatarsus of Merino sheep, measuring the distraction forces by means of an instrumented fixator. The tissue relaxation after distraction was analyzed in this study. A viscoelastic model was also applied to distraction data to assess the mechanical behavior of the tissues during the distraction phase. Tissue relaxation is similar to other bone regeneration processes which do not imply surrounding soft tissue extension, e.g. bone transport. The effects of this tissue on distraction forces are limited to the first minutes of distraction and elongations above 4% of the original length with the protocol applied. Moreover, the surrounding soft tissue initially loses some of its viscoelasticity and subsequently suffers strain hardening from day 5 of distraction until the end of the distraction phase, day 15. Finally, anatomical changes were also evidenced in the elongated limb of our specimens. We thank the Junta de Andalucía and the Ministerio de Economía y Competitividad from the Government of Spain for funding this research (US1261691, DPI2017-82501-P and PGC2018-097257-BC31), and the FPU Grant of one of the authors (FPU17/05361). |
| Databáze: | OpenAIRE |
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