Synthetic connectivity, emergence, and self-regeneration in the network of prebiotic chemistry

Autor:	Barbara Mikulak-Klucznik, Grzegorz Spólnik, Bartosz A. Grzybowski, Sara Szymkuć, Agnieszka Wołos, Wiktor Beker, Rafał Roszak, Miroslaw Dygas, Anna Żądło-Dobrowolska
Rok vydání:	2020
Předmět:	Multidisciplinary Chemistry Prebiotic medicine.medical_treatment Origin of Life Self regeneration Chemical reaction Combinatorial chemistry Prebiotic chemistry Abiogenesis medicine Molecule Computer Simulation Organic Chemicals
Zdroj:	Science. 369
ISSN:	1095-9203 0036-8075
DOI:	10.1126/science.aaw1955
Popis:	Mapping primordial reaction networks Chemists seeking to understand the origins of life have published a wide range of reactions that may have yielded the building blocks of proteins, nucleic acids, and lipids from simple precursors. Wołos et al. scoured the literature to document each such reaction class and then wrote software that applied the reactions first to the simplest compounds such as cyanide, water, and ammonia, and then iteratively to each successive generation of products. The resulting network predicted a variety of previously unappreciated routes to biochemically relevant compounds, several of which the authors validated experimentally. Science , this issue p. eaaw1955
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0caa41a53b637792c1134ef97551071 https://doi.org/10.1126/science.aaw1955 Zobrazit plný text záznamu