The impact of atrial fibrillation and long-term oral anticoagulant use on all-cause and cardiovascular mortality:A 12-year evaluation of the prospective Brazilian Study of Stroke Mortality and Morbidity
| Autor: | Alessandra C. Goulart, Paulo A. Lotufo, Gisela Tunes, Gregory Y.H. Lip, Isabela M. Benseñor, Rodrigo Díaz Olmos, Neil Thomas, Airlane Pereira Alencar, Itamar S. Santos |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
medicine.medical_specialty
Neurology stroke in developing countries ESTATÍSTICA APLICADA Stroke mortality Stroke/epidemiology Risk Factors Atrial Fibrillation medicine Humans Prospective Studies Cardiovascular mortality Fibrillation Stroke epidemiology business.industry Incidence Anticoagulants Atrial fibrillation medicine.disease Stroke Anticoagulants/therapeutic use Emergency medicine Cohort Oral anticoagulant stroke prevention medicine.symptom business Atrial Fibrillation/complications All cause mortality |
| Zdroj: | Goulart, A C, Olmos, R D, Santos, I S, Tunes, G, Alencar, A P, Thomas, N, Lip, G Y H, Lotufo, P A & Benseñor, I M 2022, ' The impact of atrial fibrillation and long-term oral anticoagulant use on all-cause and cardiovascular mortality : A 12-year evaluation of the prospective Brazilian Study of Stroke Mortality and Morbidity ', International Journal of Stroke, vol. 17, no. 1, pp. 48-58 . https://doi.org/10.1177/1747493021995592 Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| DOI: | 10.1177/1747493021995592 |
| Popis: | Background Atrial fibrillation is a predictor of poor prognosis after stroke. Aims To evaluate atrial fibrillation and all-cause and cardiovascular mortality in a stroke cohort with low socioeconomic status, taking into consideration oral anticoagulant use during 12-year follow-up. Methods All-cause mortality was analyzed by Kaplan–Meier survival curve and Cox regression models to estimate hazard ratios and 95% confidence intervals (95% CI). For specific mortality causes, cumulative incidence functions were computed. A logit link function was used to calculate odds ratios (OR) with 95% CIs. Full models were adjusted by age, sex, oral anticoagulant use (as a time-dependent variable) and cardiovascular risk factors. Results Of 1121 ischemic stroke participants, 17.8% had atrial fibrillation. Overall, 654 deaths (58.3%) were observed. Survival rate was lower (median days, interquartile range-IQR) among those with atrial fibrillation (531, IQR: 46–2039) vs. non-atrial fibrillation (1808, IQR: 334–3301), p-log rank Conclusions Among individuals with low socioeconomic status, atrial fibrillation was an independent predictor of poor survival, increasing all-cause and cardiovascular mortality risk. Long-term oral anticoagulant use was associated with a markedly reduced risk of all-cause and stroke mortality. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|