Myocarditis in 2020
| Autor: | Nikolaos Tzemos, Tahir S Kafil |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pathology
medicine.medical_specialty positron emission tomography Myocarditis Immune checkpoint inhibitors immune checkpoint inhibitor ATG antithymocyte globulin cTnI cardiac troponin I cardiac magnetic resonance ECG electrocardiography ULN upper limit of normal antithymocyte globulin LVEF left ventricular ejection fraction melanoma medicine Mini-Focus Issue: Myocardial and Pericardial Inflammation Diseases of the circulatory (Cardiovascular) system ipilimumab nivolumab Introduction medicine.diagnostic_test business.industry CPB checkpoint blockade medicine.disease Positron emission tomography RC666-701 Case Report: Clinical Case myocarditis Cardiology and Cardiovascular Medicine business Cardiac magnetic resonance MRI magnetic resonance imaging CK-MB creatine kinase–myocardial band |
| Zdroj: | JACC: Case Reports, Vol 2, Iss 2, Pp 178-179 (2020) JACC Case Reports |
| ISSN: | 2666-0849 |
| DOI: | 10.1016/j.jaccas.2020.01.004 |
| Popis: | Ipilimumab and nivolumab for melanoma induced smoldering myocarditis remitting with steroids. Rechallenge with nivolumab produced steroid-refractory myocarditis confirmed by electron microscopy. Tacrolimus and mycophenolate transiently reduced inflammation, but antithymocyte globulin induced remission. Cardiomyopathy with fatty infiltration ensued, but the patient succumbed to rampant melanoma progression after lymphocyte depletion. (Level of Difficulty: Advanced.) Graphical abstract Ipilimumab and nivolumab for melanoma induced smoldering myocarditis remitting with steroids. Rechallenge with nivolumab produced steroid-refractory… |
| Databáze: | OpenAIRE |
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