Pharmacokinetic-hemodynamic studies of the enantiomers of isoidide dinitrate in conscious rats
| Autor: | Brian M. Bennett, R. Baur, J. W. Kempenaar, L. D. Hayward |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
Physiology Metabolite Vasodilator Agents Hemodynamics Administration Oral Biological Availability Blood Pressure chemistry.chemical_compound Sugar Alcohols Pharmacokinetics Oral administration Heart Rate Physiology (medical) Animals Biotransformation Pharmacology Chemistry Isoidide dinitrate Rats Inbred Strains Stereoisomerism General Medicine Bioavailability Rats Anesthesia Injections Intravenous Enantiomer |
| Zdroj: | Canadian journal of physiology and pharmacology. 69(9) |
| ISSN: | 0008-4212 |
| Popis: | Our objective was to determine the pharmacokinetic properties of the D- and L-enantiomers of isoidide dinitrate (IIDN) in relation to their hemodynamic effects. Conscious male Sprague–Dawley rats were administered a bolus i.v. dose of 2 mg∙kg−1D- or L-IIDN and simultaneous blood samples and blood pressure recordings were taken at various times. The elimination half-life of D-IIDN was significantly shorter than that of L-IIDN (10 vs. 16 min) owing to a larger Vd area of the L-enantiomer (5.8 vs. 3.8 L∙kg−1). The plasma clearance of either enantiomer was approximately 250 mL∙min−1∙kg−1 a value equal to plasma cardiac output. The pharmacokinetic data indicates that IIDN is distributed extensively and that significant extrahepatic biotransformation of the drug occurs. After intravenous administration of D-IIDN, there was an initial decrease in mean arterial pressure (MAP) of 29% compared with 15% for L-IIDN (p |
| Databáze: | OpenAIRE |
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