Polymorphism of circadian clock genes and temperamental dimensions of the TEMPS-A in bipolar disorder
| Autor: | Karen K. Akiskal, Joanna Hauser, Daria Dembińska-Krajewska, Hagop H. Akiskal, Monika Dmitrzak-Weglarz, Janusz K. Rybakowski |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Hyperthymic temperament Bipolar Disorder Genotype Personality Inventory media_common.quotation_subject CLOCK Proteins Single-nucleotide polymorphism Cell Cycle Proteins ARNTL Gene Polymorphism Single Nucleotide Circadian Clocks Surveys and Questionnaires mental disorders medicine Humans Bipolar disorder Temperament media_common Aged Genetics ARNTL Transcription Factors Intracellular Signaling Peptides and Proteins Period Circadian Proteins Middle Aged medicine.disease ARNTL Psychiatry and Mental health Clinical Psychology Female Psychology |
| Zdroj: | Journal of affective disorders. 159 |
| ISSN: | 1573-2517 |
| Popis: | Background Previously, we found correlations between lithium efficacy in bipolar disorder and temperamental dimensions of the TEMPS-A and also genes involved in the regulation of biological rhythms (“clock” genes). Here, were attempted to investigate an association between multiple, single nucleotide polymorphisms (SNPs) of four clock genes ( CLOCK, ARNTL, TIM, PER3 ) and temperamental dimensions of the TEMPS-A, in bipolar patients. Methods The study included 70 patients with bipolar disorder (20 males, 50 females), with a mean age of 59±12 years. The TEMPS-A questionnaire, 110 questions version, was used assessing five temperament domains: depressive, cyclothymic, hyperthymic, irritable and anxious. Genotyping was done for 9 SNPs of the CLOCK gene, 18 SNPs of the ARNTL gene, 6 SNPs of the TIM gene and 5 SNPs of the PER3 gene. Results An association with hyperthymic temperament was found for three, and with anxious temperament for four SNPs of the ARTL gene. An association of cyclothymic temperament was found with two SNPs of the TIM gene and of depressive temperament with one SNP of the PER3 gene. No association was observed with SNPs of the CLOCK gene. Limitations Relatively small number of patients studied and insufficient correction for multiple testing. Conclusions These results may suggest that the ARNTL, TIM and PER3 genes may be associated with temperamental dimensions measured by the TEMPS-A, each of this gene being specific to given temperamental dimension. Of special interest may be the polymorphisms of ARNTL gene also connected with predisposition to bipolar mood disorder and/or lithium response. |
| Databáze: | OpenAIRE |
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