Tailored Treatment Based on Helicobacter pylori Genetic Markers of Resistance Is Associated With Higher Eradication Success

Autor:	Linda C, Cummings, Leila S, Hojat, David C, Nguyen, Lisa M, Stempak, Daniel D, Rhoads, Navid, Sadri
Rok vydání:	2022
Předmět:	Hepatology Gastroenterology
Zdroj:	American Journal of Gastroenterology. 118:360-363
ISSN:	1572-0241 0002-9270
DOI:	10.14309/ajg.0000000000002085
Popis:	Increasing antimicrobial resistance with Helicobacter pylori infection has focused efforts to tailor eradication therapy based on identifying genetic markers of resistance to predict antimicrobial susceptibility. In this retrospective study, we report the impact of routine inclusion of antimicrobial susceptibility testing and recommendations for eradication therapy with gastric specimens with H. pylori. The use of a recommended treatment regimen based on genetic markers of resistance was associated with an 84% rate of eradication success and 4.4 greater odds of eradication relative to unrecommended treatment. This is the first study describing use of H. pylori genetic resistance testing as standard of care.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0bcba60612249110fe6eb6ec76636fd https://doi.org/10.14309/ajg.0000000000002085 Zobrazit plný text záznamu