Spatial relationship between neuronal activity and BOLD functional MRI
| Autor: | Cheryl A. Olman, Itamar Ronen, Dae-Shik Kim, Kamil Ugurbil, Louis J. Toth, Seong-Gi Kim |
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| Rok vydání: | 2004 |
| Předmět: |
genetic structures
Photic Stimulation Brain activity and meditation Cognitive Neuroscience behavioral disciplines and activities medicine Animals Premovement neuronal activity Visual Cortex Cerebral Cortex Neurons Sensory stimulation therapy medicine.diagnostic_test Brain Magnetic resonance imaging Magnetic Resonance Imaging Electrodes Implanted Oxygen nervous system Neurology Cerebral blood flow Receptive field Cerebrovascular Circulation Cats Functional magnetic resonance imaging Psychology Neuroscience psychological phenomena and processes |
| Zdroj: | NeuroImage. 21:876-885 |
| ISSN: | 1053-8119 |
| DOI: | 10.1016/j.neuroimage.2003.10.018 |
| Popis: | Despite the ubiquitous use of functional magnetic resonance imaging (fMRI), the extent to which the magnitude and spatial scale of the fMRI signal correlates with neuronal activity is poorly understood. In this study, we directly compared single and multiunit neuronal activity with blood oxygenation level-dependent (BOLD) fMRI responses across a large area of the cat area 18. Our data suggest that at the scale of several millimeters, the BOLD contrast correlates linearly with the underlying neuronal activity. At the level of individual electrode recording sites, however, the correlation between the two signals varied substantially. We conclude from our study that T(2)*-based positive BOLD signals are a robust predictor for neuronal activity only at supra-millimeter spatial scales. |
| Databáze: | OpenAIRE |
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