Evaluation of Antifungal and DNA-Damaging Activities of Alkaloids from Branches of Porcelia macrocarpa
| Autor: | Mariana Helena Chaves, Maria Claudia Marx Young, Mariane Cruz Costa Ayres, Debora G. Agripino, João Henrique G. Lago |
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| Rok vydání: | 2007 |
| Předmět: |
Antifungal Agents
Stereochemistry Saccharomyces cerevisiae Mutant Annonaceae Pharmaceutical Science Cladosporium cladosporioides Microbial Sensitivity Tests Aporphines Fractionation Biology Pharmacognosy Analytical Chemistry Alkaloids Drug Discovery Humans Pharmacology Plant Extracts Alkaloid Organic Chemistry Plant Components Aerial biology.organism_classification Yeast Complementary and alternative medicine Molecular Medicine Cladosporium DNA Damage Phytotherapy |
| Zdroj: | Planta Medica. 73:292-295 |
| ISSN: | 1439-0221 0032-0943 |
| DOI: | 10.1055/s-2007-967108 |
| Popis: | Bioactivity-guided fractionation of the alkaloidal fractions of the CH 2 Cl 2 extract from branches of PORCELIA MACROCARPA using mutant yeast strains of SACCHAROMYCES CEREVISIAE and fungi CLADOSPORIUM CLADOSPORIOIDES and C. SPHAEROSPERMUM led to the isolation of bioactive alkaloids: two tetrahydrobenzylisoquinolines ( 1 and 2), two aporphines ( 3 and 4), one proaporphine ( 5), one oxoaporphine ( 6), four azantraquinones ( 7 - 10) and four azafluorenones ( 11 - 14). The alkaloids cleistopholine ( 7) and 6-methoxycleistopholine ( 8) showed the highest fungitoxic activity while the mixture of 6- and 7-methoxyonychine ( 12 + 13) and 6,7-dimethoxyonychine ( 14) showed a weak DNA-damaging potential. |
| Databáze: | OpenAIRE |
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