Evaluation of healing prosthetic materials polyester mesh resorbable film and collagen elastin matrix /polypropylene used in rabbits abdominal wall defects
| Autor: | Leticia Elizabeth Augustin Czeczko, Ulrich A. Dietz, Larissa Santin Garcia, Danielle Duck Schulz, Nicolau Gregori Czeczko, Gustavo Justo Schulz, Osvado Malafaia |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Materials science
Hernia Polyesters Tissue Adhesions Polypropylenes Collagen Type I Statistics Nonparametric Abdominal wall Suture (anatomy) Absorbable Implants Materials Testing Matrix Metalloproteinase 13 medicine Animals Rabitts Analysis of Variance Wound Healing biology Abdominal Wall Adhesion Surgical Mesh Immunohistochemistry Elastin Polyester Collagen Type III medicine.anatomical_structure Surgical mesh Models Animal biology.protein Female Surgery Collagen Rabbits Implant Layer (electronics) Biomedical engineering |
| Zdroj: | Acta Cirúrgica Brasileira v.24 n.6 2009 Acta Cirúrgica Brasileira Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
| Popis: | PURPOSE: To compare polyester with absorbable layer prosthesis with collagen-elastin/polypropylene prosthesis in the repair of abdominal wall defects. METHODS: The 16 studied rabbits were divided in groups A and B (euthanized on the 30th and 60th days, after the implant of the mesh). The animals underwent laparotomy and received a 2cm wall "defect" on each side of the Alba linea. The repair was made with the suture of a polyester mesh with absorbable film on the left side of the Alba Linea and with collagen-elastin/polypropylene mesh on the right side. Adherences were classified according to Nair Score and microscopic evaluation observing types I and III collagen formation and other immunohistochemical analyses. RESULTS: There were no significant differences in adhesion formation. The collagen type I showed higher deposition in polyester with absorbable layer. In group B, the difference between the meshes was significant, with higher collagen III deposition in polyester with absorbable layer (60º P.O.). About the metalloproteinases, the presence of MMP -1 and MMP-8 were about the same; the expression of MMP-13 increased near to the 60th day. CONCLUSIONS: There is no significant difference between the two meshes in adhesion formation and immunohystochemical evaluation. The polyester mesh resorbable film presented a higher deposition of collagen. |
| Databáze: | OpenAIRE |
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