Direct immunofluorescence for immunobullous and other skin diseases
Autor: | Amene Saghazadeh, Nima Rezaei, Maryam Daneshpazhooh, Alireza Ghanadan |
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Rok vydání: | 2015 |
Předmět: |
Pathology
medicine.medical_specialty Immunology Antigen-Antibody Complex Skin Diseases Antibodies Basement Membrane Basement membrane zone Blood vessel walls Immunology and Allergy Medicine Animals Humans Antigens Direct fluorescent antibody Dermoepidermal junction Target antigen business.industry fungi humanities medicine.anatomical_structure Fluorescent Antibody Technique Direct Blood Vessels Epidermis business |
Zdroj: | Expert review of clinical immunology. 11(5) |
ISSN: | 1744-8409 |
Popis: | A swift glance at ample evidence currently available about the assay clearly illustrates that the development of direct immunofluorescence (DIF), in which direct fluorescent antibodies are utilized to identify the target antigen, has been of immense importance. The immunoreactant deposits have been delineated by the DIF assay in three main locations, including throughout the epidermis, at the dermoepidermal junction (also known as the basement membrane zone) and in and/or around blood vessel walls. DIF testing can be conducted on several specimen sources, which are categorized according to feasibility of collection into invasive (e.g., skin) and non-invasive (e.g., hair). This review was intended to indicate that inspection of immunoreactant deposits via DIF is highly instrumental in diagnosing and monitoring the immunobullous and other diseases of the skin. |
Databáze: | OpenAIRE |
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