Postnatal Treatment With Dexamethasone Perturbs Hepatic and Cardiac Energy Metabolism and Is Associated With a Sustained Atherogenic Plasma Lipid Profile in Suckling Rats
| Autor: | Folkert Kuipers, Feike R van der Leij, Rick Havinga, Pieter J. J. Sauer, Dirk-Jan Reijngoud, Vincent W. Bloks, Yan Liu, J. F. W. Baller |
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| Přispěvatelé: | Center for Liver, Digestive and Metabolic Diseases (CLDM) |
| Rok vydání: | 2007 |
| Předmět: |
Blood Glucose
EXPRESSION Cardiac function curve medicine.medical_specialty medicine.medical_treatment Ketone Bodies Sodium Chloride Biology Carbohydrate metabolism Dexamethasone DEFICIENT MICE NEONATAL GLUCOCORTICOSTEROID TREATMENT EARLY-LIFE Insulin resistance Pregnancy PRETERM INFANTS Internal medicine Blood plasma Hyperlipidemia medicine Animals Rats Wistar Glucocorticoids Beta oxidation Myocardium Insulin Fatty Acids GLUCOSE-METABOLISM medicine.disease Lipids INSULIN DYSFUNCTION Animals Suckling Rats Endocrinology Animals Newborn Liver Pediatrics Perinatology and Child Health HEART Female FATTY-ACIDS Energy Metabolism hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Pediatric Research, 61(2), 165-170. Nature Publishing Group |
| ISSN: | 1530-0447 0031-3998 |
| Popis: | Early exposure to glucocorticoids (GC) has been proposed to disturb hepatic and cardiac function in later life. In the present study, we evaluated early metabolic alterations upon GC treatment that may predispose to long-term abnormalities. Rats were injected with dexamethasone (DEX) at d 1, 2, and 3 after birth and controls received saline (SAL). Rats were killed at 2, 7, and 14 d of age. Compared with SAL, DEX induced lower plasma insulin levels, hyperglycemia, hyperketonemia, and dyslipidemia at 2 d. At the same time, DEX treatment significantly increased expression of gluconeogenic and fatty acid oxidation genes in liver and expression of genes involved fatty acid utilization in heart. At 7 d, DEX-treated rats showed insulin resistance with hyperlipidemia, whereas hepatic and cardiac gene expression patterns were largely normalized. Hyperlipidemia and a significantly increased hepatic triglyceride content in DEX-treated rats were prominent at 14 d without large differences in hepatic and cardiac gene expression patterns. Thus, neonatal DEX administration transiently affects cardiac and hepatic gene expression patterns in suckling rats associated with sustained effects on plasma glucose and lipid concentrations. Whether these early effects of DEX contribute to hepatic and cardiac abnormalities at adult age needs further evaluation. |
| Databáze: | OpenAIRE |
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