1241. Surveillance for Viral Respiratory Infections in Pediatric Chronic Care Facilities
| Autor: | Natalie Neu, Lindsay Kim, Xiaoyan Lu, Elaine Larson, Mila M. Prill, Brett Whitaker, Sibyl Wilmont, Shikha Garg, Nimalie D. Stone, Susan I. Gerber, Lisa Saiman |
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| Rok vydání: | 2018 |
| Předmět: |
Chronic care
medicine.medical_specialty biology Respiratory tract infections business.industry Human bocavirus Clinical Neurology medicine.disease_cause biology.organism_classification respiratory tract diseases Vaccination Abstracts Infectious Diseases B. Poster Abstracts Oncology Specimen collection Parechovirus medicine Rhinovirus Viral shedding Intensive care medicine business |
| Zdroj: | Open Forum Infectious Diseases |
| ISSN: | 2328-8957 |
| DOI: | 10.1093/ofid/ofy210.1074 |
| Popis: | Background Residents of pediatric chronic care facilities (PCCFs) are vulnerable to acute respiratory infections (ARIs) due to their underlying medical conditions and infection control challenges in congregate living. Methods We conducted active, prospective surveillance for ARIs (defined as ≥2 new signs/symptoms of respiratory illness) among all residents in three PCCFs near New York City from December 7, 2016 to May 7, 2017. The parents/guardians of some residents also provided consent for research specimen collection at the start of the study. In that subset, nasopharyngeal swabs were obtained ≤4 days of ARI symptom onset and weekly for 4 weeks of follow-up to assess viral shedding. Influenza, respiratory syncytial virus (RSV), rhinovirus (RV), coronavirus (229E, NL63, OC43, HKU1), parainfluenzavirus (PIV 1–4), metapneumovirus (MPV), adenovirus (AdV), bocavirus (BoV), enterovirus, parechovirus, and M. pneumoniae were tested by the Fast Track Diagnostics Respiratory Pathogens 21 real-time RT-PCR panel. Results Subset with research specimen collection: Among 79 residents (aged 0–20 years, median = 8), 60 ARIs were reported in 37 (47%) residents. Swabs were obtained at illness onset for 53/60 ARI episodes; among these, there were 25 single-virus detections and five co-detections. An additional 33 single- and five co-detections occurred in 175 follow-up swabs (table). Molecular typing of 32 RV+ specimens identified 13 RV types. All residents: During the 2016–2017 influenza season, 308/322 (96%) age-eligible residents received influenza vaccine and 168/364 (46%) received prophylactic antivirals for influenza exposures. Although influenza was not detected in research swabs, it was detected in 3/200 tests conducted for clinical purposes. Conclusion ARIs were common among residents of three PCCFs, and a variety of respiratory viruses were detected. The rarity of influenza may reflect strong infection control practices in these facilities, including vaccination and prophylactic use of antivirals. Disclosures All authors: No reported disclosures. |
| Databáze: | OpenAIRE |
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