Biobehavioral Research and Hematopoietic Stem Cell Transplantation: Expert Review from the Biobehavioral Research Special Interest Group of the American Society for Transplantation and Cellular Therapy
| Autor: | William A. Wood, Kelly E. Rentscher, Mallory Taylor, Heather S.L. Jim, Bronwen E. Shaw, Effie W. Petersdorf, Karen L. Syrjala, Erin S. Costanzo, Anna Barata, Anela Carrazana Yero, Keayra E. Morris, Debra Lynch Kelly, Amanda Emmrich, Jennifer M. Knight, Shahrukh K. Hashmi, Kathryn E. Flynn, Linda J. Burns |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Cell- and Tissue-Based Therapy Context (language use) Hematopoietic stem cell transplantation Article Cell therapy Immune Reconstitution Quality of life (healthcare) Survivorship curve medicine Immunology and Allergy Intensive care medicine Adverse effect Transplantation business.industry Hematopoietic Stem Cell Transplantation Cell Biology Hematology Special Interest Group United States Public Opinion Quality of Life Molecular Medicine business |
| Zdroj: | Transplant Cell Ther |
| ISSN: | 2666-6367 |
| DOI: | 10.1016/j.jtct.2021.06.007 |
| Popis: | Hematopoietic stem cell transplantation (HCT) is a potentially curative treatment for many hematologic conditions. Despite advances in conditioning and supportive measures, however, there remain significant comorbidities that threaten survivorship. Adverse effects of stress-related biobehavioral processes—defined here as the interactions of behavioral, psychological, and socioenvironmental factors with biology—impact immune recovery and function and are particularly salient in the HCT context, given the importance of immune reconstitution for improved survivorship. However, biobehavioral processes have been underinvestigated in this vulnerable group compared with other cancer populations. Here the Biobehavioral Research Special Interest Group (SIG) of the American Society for Transplantation and Cellular Therapy provides an expert review to inform research directions explicating the biological correlates of behavioral symptoms and evaluate the impact of these on HCT outcomes. The goal of this expert review is to provide a foundation for advancing science that effectively integrates behavioral and biological processes to optimize quality of life and improve clinical outcomes for HCT recipients. |
| Databáze: | OpenAIRE |
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