Dietary geraniol by oral or enema administration strongly reduces dysbiosis and systemic inflammation in dextran sulfate sodium-treated mice
| Autor: | Chiara Ricci, Antonio Strillacci, Manuela Centanni, Maria Chiara Valerii, Marco Candela, Fernando Rizzello, Enzo Spisni, Luigia De Fazio, Elena Cavazza, Massimo Campieri |
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| Přispěvatelé: | De Fazio, Luigia, Spisni, Enzo, Cavazza, Elena, Strillacci, Antonio, Candela, Marco, Centanni, Manuela, Ricci, Chiara, Rizzello, Fernando, Campieri, Massimo, Valerii, Maria C. |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Drug Preservative Geraniol medicine.medical_treatment media_common.quotation_subject Inflammation Pharmacology Systemic inflammation Inflammatory bowel disease 03 medical and health sciences dextran sulfate sodium (DSS)-induced colitis Dextran sulfate sodium (DSS)-induced coliti medicine Pharmacology (medical) Colitis Cyclooxygenase-2 Original Research media_common business.industry lcsh:RM1-950 dysbiosis Enema medicine.disease Antimicrobial geraniol Dextran sulfate sodium Colorectal cancer Dysbiosi Dextran sulphate sodium (DSS)-induced colitis 030104 developmental biology lcsh:Therapeutics. Pharmacology Immunology Inflammatory bowel disease (IBD) Dysbiosis medicine.symptom business Cyclooxygenase-2 (COX-2) |
| Zdroj: | Frontiers in Pharmacology, Vol 7 (2016) Frontiers in Pharmacology |
| Popis: | (Trans)-3,7-Dimethyl-2,6-octadien-1-ol, commonly called geraniol (Ge-OH), is an acyclic monoterpene alcohol with well-known anti-inflammatory, antitumoral, and antimicrobial properties. It is widely used as a preservative in the food industry and as an antimicrobial agent in animal farming. The present study investigated the role of Ge-OH as an anti-inflammatory and anti-dysbiotic agent in the dextran sulfate sodium (DSS)-induced colitis mouse model. Ge-OH was orally administered to C57BL/6 mice at daily doses of 30 and 120 mg kg((-1)) body weight, starting 6 days before DSS treatment and ending the day after DSS removal. Furthermore, Ge-OH 120 mg kg((-1)) dose body weight was administered via enema during the acute phase of colitis to facilitate its on-site action. The results show that orally or enema-administered Ge-OH is a powerful antimicrobial agent able to prevent colitis-associated dysbiosis and decrease the inflammatory systemic profile of colitic mice. As a whole, Ge-OH strongly improved the clinical signs of colitis and significantly reduced cyclooxygenase-2 (COX-2) expression in colonocytes and in the gut wall. Ge-OH could be a powerful drug for the treatment of intestinal inflammation and dysbiosis. |
| Databáze: | OpenAIRE |
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