TMC-2A, -2B and -2C, New Dipeptidyl Peptidase IV Inhibitors Produced by Aspergillus oryzae A374. II. Isolation and Structure Determination
| Autor: | Maki Nishio, Saburo Komatsubara, Tadamasa Date, Takahisa Sugita, Kimio Okamura, Nobuaki Nonaka, Tetsuo Ohnuki, Yasuyuki Asai |
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| Rok vydání: | 1997 |
| Předmět: |
Indoles
Stereochemistry Crystallography X-Ray chemistry.chemical_compound Aspergillus oryzae Drug Discovery Molecule Amino Acids Enzyme Inhibitors Isoquinoline Dipeptidyl-Peptidases and Tripeptidyl-Peptidases Dipeptidyl-Peptidase IV Inhibitors Pharmacology chemistry.chemical_classification Molecular Structure biology Chemistry food and beverages Fungi imperfecti Isoquinolines biology.organism_classification In vitro Enzyme Enzyme inhibitor Fermentation biology.protein |
| Zdroj: | The Journal of Antibiotics. 50:653-658 |
| ISSN: | 1881-1469 0021-8820 |
| Popis: | New dipeptidyl peptidase IV inhibitors, TMC-2A, -2B, and -2C, were isolated from the fermentation broth of Aspergillus oryzae A374. On the basis of chemical, spectroscopic and X-ray crystallographic analyses, their structures were established to be peptide-like compounds composed of three moieties, L-tryptophan, mono- or dihydroxy-L-leucine and highly substituted isoquinoline. |
| Databáze: | OpenAIRE |
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