Carnitine synthesis in rat tissue slices
| Autor: | Harry T. Haigler, Harry P. Broquist |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Male
Lysine Biophysics In Vitro Techniques Biology Kidney Tritium Biochemistry Carnitine Testis medicine Animals Molecular Biology chemistry.chemical_classification Muscles Myocardium Cell Biology Chromatography Ion Exchange Carnitine synthesis In vitro Rats Betaine Butyrates medicine.anatomical_structure Enzyme Liver chemistry Organ Specificity Rat liver Testis tissue Chromatography Thin Layer medicine.drug |
| Zdroj: | Biochemical and Biophysical Research Communications. 56:676-681 |
| ISSN: | 0006-291X |
| Popis: | The ability of rat liver, kidney, muscle, heart and testis tissue to carry out the in vitro synthesis of carnitine via e-N-trimethyllysine and γ-butyrobetaine was studied. All tissues formed γ-butyrobetaine from trimethyllysine, but liver and testis also formed carnitine in about 7% and 1% yield respectively. Liver slices formed trimethyllysine from lysine in about 6% yield. These in vitro studies thus establish that liver has all the enzymes of the carnitine biosynthetic pathway. This tissue appears to be the primary site of carnitine synthesis in the rat as implied from whole animal studies in this and other laboratories. |
| Databáze: | OpenAIRE |
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