| Popis: |
How cells become specialized, or “mature”, is important for cell and developmental biology. While maturity is usually deemed a terminal fate, it may be more helpful to consider maturation not as a switch, but a dynamic continuum of adaptive phenotypic states set by genetic and environment programming. The hallmarks of maturity comprise changes in anatomy (form, gene circuitry, interconnectivity) and physiology (function, rhythms, proliferation) that confer adaptive behavior. We discuss efforts to harness their chemical (nutrients, oxygen, growth factors) and physical (mechanical, spatial, electrical) triggers in vitro and in vivo, and how maturation strategies may support disease research and regenerative medicine. |
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