Differentiation between vestibular schwannomas and meningiomas with atypical appearance using diffusion kurtosis imaging and three-dimensional arterial spin labeling imaging
Autor: | Tianjin Zhong, Qing Duan, Xiaoqiang Du, Lin Lin, Ganggang Xu, Xiaodan Chen, Yunjing Xue, Rifeng Jiang |
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Rok vydání: | 2018 |
Předmět: |
Male
Sensitivity and Specificity 030218 nuclear medicine & medical imaging Diagnosis Differential 03 medical and health sciences Imaging Three-Dimensional 0302 clinical medicine Fractional anisotropy Meningeal Neoplasms otorhinolaryngologic diseases Humans Medicine Radiology Nuclear Medicine and imaging Diffusion Kurtosis Imaging Receiver operating characteristic business.industry Reproducibility of Results Neuroma Acoustic General Medicine Middle Aged nervous system diseases Diffusion Magnetic Resonance Imaging Diffusion Tensor Imaging ROC Curve Cerebral blood flow Cerebrovascular Circulation Vestibular Schwannomas Arterial spin labeling Kurtosis Treatment strategy Female Spin Labels Meningioma business Nuclear medicine 030217 neurology & neurosurgery |
Zdroj: | European Journal of Radiology. 109:13-18 |
ISSN: | 0720-048X |
DOI: | 10.1016/j.ejrad.2018.10.009 |
Popis: | An accurate differentiation between vestibular schwannomas (VS) and meningiomas is critical in determining treatment strategies and clinical prognoses. However, misdiagnoses may occur when typical imaging appearances are absent. The purpose of this study was to assess the performances of diffusion kurtosis imaging (DKI) and three-dimensional arterial spin labeling imaging (3D-ASL) in the differentiation of VS and meningiomas with atypical appearance.Thirty-eight patients with pathologically proven VS and meningiomas were consecutively enrolled. All patients had no typical appearance and underwent DKI and 3D-ASL scan. Then, the DKI and 3D-ASL parameters were measured. Statistical analyses were performed using independent-sample t-tests, Mann-Whitney U tests and receiver operating characteristic (ROC) curve analyses.Mean kurtosis (MK), radial kurtosis (RK), axial kurtosis (AK), fractional anisotropy (FA) and cerebral blood flow (CBF) were significantly lower in VS than those in meningiomas, mean diffusivity (MD) were significantly higher in VS than that in meningiomas (all P 0.05). ROC curve analyses showed that the diagnostic performance of kurtosis values outperformed those of other MR parameters. A cut-off RK value of 0.766 yielded a sensitivity of 91.67%, a specificity of 100.0%, and an accuracy of 94.74%, with an AUC of 0.988.DKI and 3D-ASL are useful for differentiating VS and meningiomas with atypical appearance, with kurtosis values of DKI have the best diagnostic efficiency. |
Databáze: | OpenAIRE |
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