3D printed alginate-cellulose nanofibers based patches for local curcumin administration
| Autor: | Borja Alonso-Lerma, Nagore Gabilondo, Raul Perez-Jimenez, Arantxa Eceiza, R. Olmos-Juste |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Scaffold
3d printed Curcumin Materials science Polymers and Plastics Alginates Nanofibers Biocompatible Materials 02 engineering and technology 010402 general chemistry 01 natural sciences Nanocellulose chemistry.chemical_compound Drug Delivery Systems X-Ray Diffraction Spectroscopy Fourier Transform Infrared Materials Chemistry Humans Cellulose Porosity Drug Carriers Tissue Scaffolds Organic Chemistry Bioprinting 021001 nanoscience & nanotechnology 0104 chemical sciences Drug Liberation Kinetics HEK293 Cells chemistry Chemical engineering Nanofiber Printing Three-Dimensional Drug delivery Rheology 0210 nano-technology |
| Zdroj: | Carbohydrate Polymers. 264:118026 |
| ISSN: | 0144-8617 |
| DOI: | 10.1016/j.carbpol.2021.118026 |
| Popis: | Alginate and nanocellulose are potential biomaterials to be employed as bioinks for three-dimensional (3D) printing. Alginate-cellulose nanofibers (A-CNF) formulations with CNF amounts up to 5 wt% were developed and rheologically characterized to evaluate their printability. Results showed that formulations with less than 3 wt% CNF did not present suitable characteristics to ensure shape fidelity after printing. Selected A-CNF bioinks were 3D printed and freeze-dried to obtain porous scaffolds. Morphological and mechanical analysis were performed, showing that CNF contributed to the reinforcement of the scaffolds and modulated their porosity. The applicability for drug delivery was evaluated by the addition of curcumin to printable A-CNF formulations. The curcumin loaded bioinks were successfully 3D printed in patches and the in vitro release tests showed that alginate and CNF played an important role in curcumin stabilization, whereas the CNF content and the disintegration of the scaffold were essential in the release kinetics. |
| Databáze: | OpenAIRE |
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