The Basolateral Nucleus of the Amygdala Executes the Parallel Processes of Avoidance and Palatability in the Retrieval of Conditioned Taste Aversion in Male Rats
| Autor: | Tsuyoshi Shimura, Yasunobu Yasoshima, Tadashi Inui, Tomoaki Sugishita, Chizuko Inui-Yamamoto |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Agonist
avoidance Male medicine.medical_specialty medicine.drug_class Conditioning Classical Amygdala chemistry.chemical_compound Internal medicine medicine Avoidance Learning Animals Palatability Rats Wistar conditioned taste aversion retrieval new method of behavioral experiment Behavior Animal Chemistry GABAA receptor Basolateral Nuclear Complex General Neuroscience musculoskeletal neural and ocular physiology Classical conditioning General Medicine biochemical phenomena metabolism and nutrition New Research 1.1 medicine.anatomical_structure Endocrinology Muscimol Cognition and Behavior palatability Taste Mental Recall Taste aversion Licking psychological phenomena and processes the basolateral nucleus of the amygdala |
| Zdroj: | eNeuro |
| ISSN: | 2373-2822 |
| Popis: | Conditioned taste aversion (CTA) is an essential behavior for animal survival. Conditioned animals show avoidance and decreased palatability to a conditioned stimulus (CS) on CTA retrieval. In this study, we aimed to determine whether the basolateral nucleus of the amygdala (BLA) is involved in CTA retrieval and whether avoidance and palatability in CTA retrieval are processed in the BLA. We developed an experimental chamber for time-course analysis of the behavior to approach a spout and lick a CS. In this experimental chamber, we analyzed the behavior of male rats following microinjections of GABAAreceptor agonist muscimol or saline into the BLA. The rats showed two types of approach behavior: they either (1) approached and licked the spout or (2) approached but did not lick the spout. Muscimol injection into the BLA decreased the frequency of the latter type of approach behavior, indicating that BLA inactivation reduced avoidance to the CS. The muscimol injection into the BLA also significantly increased the consumption of the CS. Lick microstructure analysis demonstrated that intra-BLA muscimol significantly increased licking burst number and size, indicating that BLA inactivation attenuated aversion to the CS as large burst licking is an indicator of high palatability. These results suggest that the increase in CS consumption with intra-BLA muscimol injection was due to alterations in approach and aversive responses to the CS. Therefore, we conclude that the BLA plays an essential role in CTA retrieval by parallel processing of avoidance and palatability. |
| Databáze: | OpenAIRE |
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