Age-related weakness of proximal muscle studied with motor cortical mapping: a TMS study
| Autor: | David A. Cunningham, Nicole Varnerin, Guang H. Yue, Andre G. Machado, Corin Bonnett, Alexandria Wyant, Vlodek Siemionow, Xiaofeng Wang, Juliet Hou, Daniel Janini, Ela B. Plow |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Aging Anatomy and Physiology medicine.medical_treatment lcsh:Medicine Biceps 0302 clinical medicine lcsh:Science Musculoskeletal System Brain Mapping Muscle Weakness Multidisciplinary Hand Strength 05 social sciences Motor Cortex Anatomy Transcranial Magnetic Stimulation medicine.anatomical_structure Observational Studies Proximal Muscle Medicine Female medicine.symptom Primary motor cortex Research Article Muscle Contraction Motor cortex Muscle contraction Weakness Clinical Research Design Neurophysiology Biology Neurological System 050105 experimental psychology Young Adult 03 medical and health sciences medicine Humans 0501 psychology and cognitive sciences Muscle Skeletal Aged Motor Systems lcsh:R Muscle weakness Evoked Potentials Motor Transcranial magnetic stimulation Geriatrics lcsh:Q Physiological Processes 030217 neurology & neurosurgery Neuroscience |
| Zdroj: | PLoS ONE, Vol 9, Iss 2, p e89371 (2014) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Aging-related weakness is due in part to degeneration within the central nervous system. However, it is unknown how changes to the representation of corticospinal output in the primary motor cortex (M1) relate to such weakness. Transcranial magnetic stimulation (TMS) is a noninvasive method of cortical stimulation that can map representation of corticospinal output devoted to a muscle. Using TMS, we examined age-related alterations in maps devoted to biceps brachii muscle to determine whether they predicted its age-induced weakness. Forty-seven right-handed subjects participated: 20 young (22.6 ± 0.90 years) and 27 old (74.96 ± 1.35 years). We measured strength as force of elbow flexion and electromyographic activation of biceps brachii during maximum voluntary contraction. Mapping variables included: 1) center of gravity or weighted mean location of corticospinal output, 2) size of map, 3) volume or excitation of corticospinal output, and 4) response density or corticospinal excitation per unit area. Center of gravity was more anterior in old than in young (p |
| Databáze: | OpenAIRE |
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