A solvent-free method for isotopically or radioactively labeling cyclodextrins and cyclodextrin-containing polymers
| Autor: | Stacey A. Kalovidouris, Robert Andresini, Robert Fazio, Mark E. Davis, Thomas Schluep, Ryan K. Zeidan |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Ethylene Oxide
Spectrometry Mass Electrospray Ionization Polymers Biomedical Engineering Pharmaceutical Science Bioengineering Alcohol Ring (chemistry) chemistry.chemical_compound Nucleophile Isotopes polycyclic compounds Organic chemistry Pharmacology chemistry.chemical_classification Solvent free Ethylene oxide Cyclodextrin Molecular Structure Organic Chemistry beta-Cyclodextrins technology industry and agriculture Polymer carbohydrates (lipids) chemistry Solvents Biotechnology |
| Zdroj: | Bioconjugate chemistry. 17(6) |
| ISSN: | 1043-1802 |
| Popis: | A method for installing a distinguishable label onto cyclodextrins or cyclodextrin-containing polymers is reported. Cyclodextrins (CD) and cyclodextrin-containing polymers are exposed to labeled (^2H or ^(14)C) ethylene oxide (EO) vapor and the alcohol groups on the CD ring open the EO to give ether-linked labeled methylenes and a terminal alcohol. This method provides for the incorporation of an easily tracked and quantified label without the use of solvents or purification steps. The method can be generalized for use with materials that contain nucleophiles other than alcohols, e.g., amines. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|