Celiprolol, a beta-adrenoceptor antagonist with vasodilator effect, improves hemodynamic response to catecholamine, spontaneous locomotor activity, and survival in cardiomyopathic hamsters with advanced heart failure
| Autor: | Nobuaki Tanaka, Tomoko Ohkusa, Masunori Matsuzaki, Yasuma Nakamura, Tsutomu Ryoke |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
Haemodynamic response Adrenergic beta-Antagonists Hemodynamics Motor Activity Ventricular Function Left Random Allocation Internal medicine Cricetinae Dobutamine Receptors Adrenergic beta Renin Medicine Animals Survival rate Lung Celiprolol Pharmacology Heart Failure Analysis of Variance Dose-Response Relationship Drug Mesocricetus business.industry Myocardium Body Weight Antagonist Heart Organ Size Adrenergic beta-Agonists medicine.disease Survival Rate Dose–response relationship Endocrinology Liver Heart failure Cardiology and Cardiovascular Medicine business Cardiomyopathies medicine.drug |
| Zdroj: | Journal of cardiovascular pharmacology. 31(2) |
| ISSN: | 0160-2446 |
| Popis: | To assess the effects of celiprolol, which is a selective beta1-antagonist with vasodilating properties, on chronic heart failure in the cardiomyopathic hamster UM-X7.1 (CMH), we studied survival in treated CMH (celiprolol, 100 mg/kg/day) and untreated CMH. We also measured the hamsters' locomotor activity (by using an Automex system), in vivo left ventricular (LV) pressure with or without dobutamine infusion, and the myocardial beta-adrenergic-receptor density (Bmax), all at the age of approximately 210 days. Survival was significantly improved in the treated group compared with untreated group by 33.4% at the age of 210 days, and the median probabilities of survival were age 252 days in the treated group and 203 days in the untreated group (p < 0.01). The locomotor activity count was significantly higher in the treated group (14,945+/-6,895) than in the untreated group (8,264+/-2,945 counts/day; p < 0.05). The response of LV peak +/-dP/dt to dobutamine was significantly improved in the treated group by 22.9 and 34.8%, respectively, at 18 microg/kg/min. Bmax was also higher in the treated group than in the untreated group (80.1+/-15.1 vs. 65.2+/-10.6 fmol/mg; p < 0.05). This study suggests that long-term treatment with celiprolol could improve both survival and the hemodynamic responses to dobutamine, associated with the upregulation of beta-receptors, and increased locomotor activity. |
| Databáze: | OpenAIRE |
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