| Autor: |
Christian Fischer, Bertram Wiedenmann, Jane Y. Wu, Marcus Bahra, Rosa Schmuck, Ruza Arsenic, Martina Welzel, Jan L. Körner, Georg Hilfenhaus, Katharina M. Detjen, Andreas Göhrig |
| Rok vydání: |
2023 |
| DOI: |
10.1158/0008-5472.22402092.v1 |
| Popis: |
PDF file - 643KB, Figure S1: Reactivation of Slit2 expression in Panc1 cells by 5-AZA-dC suggests silencing of Slit2 gene due to promoter hypermethylation. Figure S2: Slit2 inhibits directed migration of pancreatic tumor cells. Figure S3: Re-expression of Slit2 does not affect random migration of MiaPaCaTR-Slit2 Cells. Figure S4: Doxycycline treatment results in induction of Slit2 protein in MiaPaCaTR-Slit2 tumors in vivo. Figure S5: Inducible re-expression of Slit2 inhibits invasion, metastasis and angiogenesis in size-matched orthotopic pancreatic tumors. Figure S6: Stable knock down of Robo1 in pancreatic tumor cells promotes metastasis, but does not affect angiogenesis of orthotopic pancreatic tumors. Figure S7: Functional inhibition of Slit2 via Robo1-Fc stimulates angiogenesis in DANGRobo1-KD tumors subjected to Robo1 receptor knock down. Figure S8: Forced expression of Slit2 inhibits metastasis and invasion in the orthotopic Panc02 syngeneic tumor model. Figure S9: Time-lapse microscopy reveals directional navigation of tumor cells along Neuritis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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