Extraction, Hemisynthesis, and Synthesis of Canthin-6-one Analogues. Evaluation of Their Antifungal Activities

Autor:	Delphine Lagoutte, Alain Fournet, Reynald Hocquemiller, Flor Soriano-Agatón, Jean-Charles Gantier, François Roblot, Erwan Poupon
Rok vydání:	2005
Předmět:	Zanthoxylum Antifungal Agents Indoles Stereochemistry Drug Evaluation Preclinical Pharmaceutical Science Microbial Sensitivity Tests Saccharomyces cerevisiae Pharmacognosy Chemical synthesis Indole Alkaloids Analytical Chemistry Aspergillus fumigatus Structure-Activity Relationship chemistry.chemical_compound Alkaloids Trichophyton Candida albicans Drug Discovery Naphthyridines Pharmacology Plants Medicinal Molecular Structure Traditional medicine biology Alkaloid Organic Chemistry Total synthesis biology.organism_classification Complementary and alternative medicine chemistry Cryptococcus neoformans Lactam Molecular Medicine Carbolines
Zdroj:	Journal of Natural Products. 68:1581-1587
ISSN:	1520-6025 0163-3864
Popis:	Zanthoxylum chiloperone var. angustifolium was investigated. Alkaloids 1-3 from the canthin-6-one series were characterized. Derivatives 7-28 were prepared by hemisynthesis or total synthesis. All compounds were tested for in vitro antifungal activities against five pathogenic fungal strains. Analogues of canthin-6-one did not show better antifungal activities.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d09c9e9c17684e79130f01e59983980b https://doi.org/10.1021/np050250z Zobrazit plný text záznamu