Hsp70 in parasites: as an inducible protective protein and as an antigen
| Autor: | George S. Kobayashi, Bruno Maresca |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Pharmacology
Host (biology) RNA Cell Biology Biology Leishmania biology.organism_classification Microbiology Hsp70 Cellular and Molecular Neuroscience Antigen Heat shock protein Immunology Parasitic Diseases Animals Humans Molecular Medicine Macrophage HSP70 Heat-Shock Proteins RNA Messenger Antigens Molecular Biology Organism |
| Zdroj: | Experientia. 50:1067-1074 |
| ISSN: | 1420-9071 0014-4754 |
| DOI: | 10.1007/bf01923463 |
| Popis: | The heat shock (HS) response is a general homeostatic mechanism that protects cells and the entire organism from the deleterious effects of environmental stresses. It has been demonstrated that heat shock proteins (HSP) play major roles in many cellular processes, and have a unique role in several areas of cell biology, from chronic degenerative diseases to immunology, from cancer research to interaction between host and parasites. This review deals with the hsp70 gene family and with its protein product, hsp70, as an antigen when pathogens infect humans. Members of HSP have been shown to be major antigens of many pathogenic organisms when they experience a major temperature shift upwards at the onset of infection and become targets for host B and T cells. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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