LPC-DHA/EPA-Enriched Diets Increase Brain DHA and Modulate Behavior in Mice That Express Human APOE4
Autor: | Leon M. Tai, Monay Zayed, Papasani V. Subbaiah, Felecia M. Marottoli, Poorna C. R. Yalagala, Dhavamani Sugasini, Sarah B. Scheinman |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Apolipoprotein E medicine.medical_specialty APOE4 Neurosciences. Biological psychiatry. Neuropsychiatry Biology Krill oil memory 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Hippocampus (mythology) Cognitive decline SV2A General Neuroscience aging food and beverages Brief Research Report Bioavailability DHA 030104 developmental biology Lysophosphatidylcholine Endocrinology chemistry LPC-DHA Docosahexaenoic acid lipids (amino acids peptides and proteins) 030217 neurology & neurosurgery Neuroscience RC321-571 |
Zdroj: | Frontiers in Neuroscience, Vol 15 (2021) Frontiers in Neuroscience |
Popis: | Compared with APOE3, APOE4 is associated with greater age-related cognitive decline and higher risk of neurodegenerative disorders. Therefore, development of supplements that target APOE genotype-modulated processes could provide a great benefit for the aging population. Evidence suggests a link between APOE genotype and docosahexaenoic acid (DHA); however, clinical studies with current DHA supplements have produced negative results in dementia. The lack of beneficial effects with current DHA supplements may be related to limited bioavailability, as the optimal form of DHA for brain uptake is lysophosphatidylcholine (LPC)-DHA. We previously developed a method to enrich the LPC-DHA content of krill oil through lipase treatment (LT-krill oil), which resulted in fivefold higher enrichment in brain DHA levels in wild-type mice compared with untreated krill oil. Here, we evaluated the effect of a control diet, diet containing krill oil, or a diet containing LT-krill oil in APOE3- and APOE4-targeted replacement mice (APOE-TR mice; treated from 4 to 12 months of age). We found that DHA levels in the plasma and hippocampus are lower in APOE4-TR mice and that LT-krill oil increased DHA levels in the plasma and hippocampus of both APOE3- and APOE4-TR mice. In APOE4-TR mice, LT-krill oil treatment resulted in higher levels of the synaptic vesicle protein SV2A and improved performance on the novel object recognition test. In conclusion, our data demonstrate that LPC-DHA/EPA-enriched krill oil can increase brain DHA and improve memory-relevant behavior in mice that express APOE4. Therefore, long-term use of LT-krill oil supplements may on some level protect against age-related neurodegeneration. |
Databáze: | OpenAIRE |
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