Dissociation of the analgesic and rewarding effects of brain stimulation in the rat
| Autor: | Stanley A. Lorens, John A. Harvey, Libby M. Yunger |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Male
Telencephalon medicine.medical_specialty Dissociation (neuropsychology) Lateral hypothalamus Analgesic Hypothalamus Methyltyrosines Experimental and Cognitive Psychology Stimulation Alpha-methyl-p-tyrosine Norepinephrine Behavioral Neuroscience Self Stimulation Neurochemical Reward Internal medicine Reaction Time Animals Medicine Brain Chemistry business.industry Fenclonine Housing Animal Electric Stimulation Rats Endocrinology Brain stimulation Conditioning Operant Hypothalamic stimulation Analgesia business |
| Zdroj: | Physiology & Behavior. 10:909-913 |
| ISSN: | 0031-9384 |
| Popis: | Lateral hypothalamic stimulation in rats produces both rewarding and analgesic effects. In comparison to the rewarding effect, significantly higher current intensities were required to produce analgesia as measured by the hot-plate method. The analgesia did not outlast stimulation. Alpha-methyl-p-tyrosine (250 mg/kg) decreased self-stimulation rates but had no effect on stimulation-induced analgesia. It was concluded that the rewarding and analgesic effects of lateral hypothalamic stimulation involve separate neurochemical systems. |
| Databáze: | OpenAIRE |
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